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Establish in vivo screening cascades for new ocular therapeutics. Experience in handling samples from in vivo studies is required. We are seeking a motivated scientist with a passion for solving complex problems and contributing creatively within a small team environment.
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Design, execute, and interpret research requiring in-vivo biology methods including generation, breeding, and maintenance of genetically engineered mouse models; various injection and animal surgery techniques; in-vivo assessment of biomarkers and editing outcomes; longitudinal study of animal health, disease markers, and phenotypic assays; post-mortem preparation of tissue sections, IHC, and other assays.
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Collaborate closely with other groups within the early CVRM therapeutic area to provide experienced clinical insight into pre-clinical scientific activities such as target selection, lead generation and optimization, clinical pharmacology and in vivo/in vitro studies.
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Familiarity with flow cytometry and imaging-based cellular assays. Experience with in vivo cell therapy and/or virus like particle (VLP) application is preferred. We are seeking an experienced and growth-oriented Senior Research Associate for our Targeted Delivery team.
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Strong background and successful track record in bioanalytical assay development, optimization, and troubleshooting with experience in: transcriptomics, pharmacogenomic analyses and interpretation, biomarkers (including pharmacodynamic biomarkers), flow cytometry, PK, ADA, and nAb methods.
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Hands-on experience in tissue culture, plate-based assays, RNA isolation, gene expression analysis (qPCR), western blot, ELISA, multiplex protein analysis, flow cytometry preferred. Experience with hands on and/or managing in vivo work at CROs is a plus.
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Experience in biomolecular interaction analysis (Octet, SPR), molecular amplification technologies (ddPCR, qPCR), and/or flow cytometry is desirable. FlowCam, NTA, MFI), MALS/DLS, DSC, SV-AUC, FTIR, electron microscopy, or mass spectrometry will be a key differentiator.
$150ExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Independently conduct molecular biology assays including flow cytometry, biomarker screening, conventional PCR, real time PCR, western blotting, immunohistochemistry and immunofluorescence staining.
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Technical proficiency in standard molecular characterization methods such as flow cytometry, immunocytochemistry, RNA analysis (Taqman, scRNAseq, etc), and standard plate-based assays. At TREEFROG US site, this Senior Scientist will lead a team of stem cell biologists to support the pluripotent stem cell (PSC) expansion and differentiation efforts in the C-Stem capsule technology.
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You have experience designing and executing experiments utilizing multiparameter flow cytometry. The Team Alloy’s Translational Research team supports our drug discovery partners with in vitro and in vivo testing of therapeutic drug candidates across multiple modalities.
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You will establish internal and external capabilities for clinically relevant modalities including lipid nanoparticle (LNP) encapsulated large and small RNAs for in vivo administration, electroporation for ex vivo approaches and AAV encoded payloads for both.
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Hands-on experience with cell-based assays, immunoassays, tissue culture methods and other biologic characterization techniques, including ELISAs, SDS-PAGE / Western Blotting, Transfection, PCR, Flow Cytometry and Spectroscopy.
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Experience in the characterization of pluripotent stem cells, genomic sequencing methodologies, and flow cytometry. Hold role of technical leader for analytical development projects, and provide strategic and scientific input across bioprocess development projects.
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Additionally, two letters of recommendation must be sent to by the respective author indicating clearly the applicant's name and the Schorr Family Associate Research Scientist position. Basic familiarity (but not necessarily extensive operating experience) with common analytical procedures, including optical microscopy, FTIR and Raman microscopy, X-ray fluorescence, scanning electron microscopy with ED and WD detectors, liquid chromatography/mass spectrometry, GC/MS and pyrolysis GC/MS, visible/NIR/SWIR reflectance and reflectance imaging spectroscopy, and fluorescence spectrometry.
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What You'll Do: DISC is seeking to fill a 2 year renewable staff scientist position at Data Scientist III level. The Data Scientist III will work independently, but in close consultation and in cooperation with Senior Scientists.
$70,000 - $105,100 a yearFull-timeExpandApply NowActive JobUpdated Yesterday
vivo flow cytometry associate scientist jobs in Waltham, MA
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