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Excellent skills with cell culture such as primary cell culture, stable and transient protein expression, fixed and live cell imaging by IHC or immunofluorescence, flow cytometry. Collaborate with Protein Sciences to optimize the developability profiles of candidate molecules, and with In Vivo Pharmacology team to evaluate PK/PD, efficacy, and toxicity.
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Extensive hands-on experience with molecular and cell biology techniques (e.g., PCR, Western blot, ELISAs, luciferase assays, flow cytometry, immunocytochemistry/immunofluorescence) is required.
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We are seeking a highly skilled and experienced Senior/Principal Scientist with a proven track record in oncology drug discovery, in vitro and in vivo pharmacological characterization, and development.
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Experience with cell and gene therapy test methodologies (i.e. PCR, Flow Cytometry, cell-based assays). The QC Associate will support testing within the QC laboratories at our BaseCamp facility in Waltham.
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Proven experience with flow cytometry or other immunostaining-based methods. Complete analytical methods (e.g. flow cytometry, potency assays, etc.) Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years.
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Participate in translational research studies to interpret and rationalize clinical observations and screening and validate biomarker expression using archival and patients' cancer tissue samples, as well as cells and tissues from in vitro and in vivo.
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Extensive hands-on experience with standard immunological techniques including multi-parameter flow cytometry, cell sorting, immunoassays such as ELISA, Cytotoxicity, in vitro co-culture assays (MLR, PBMC cultures, etc), and reporter bioassay development.
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Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection, functional immune cell assays (proliferation, cytotoxicity, chemotaxis) and assay development is essential.
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Experience designing and interpreting mammalian cell culture or in vivo experiments, ideally in cell therapy product optimization and process development. Scientist / Senior Scientist – Computational Biology.
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Job Overview: Seeking a Research Associate II/Associate Scientist I to develop and conduct bioanalytical assays for preclinical studies on a dynamic pharmacology team. Skilled in bioanalytical assays, nucleic acid techniques, and ligand assays with ex-vivo expertise.
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An Explorer must be facile at gathering, reviewing, and integrating information regarding a potential therapeutic across multiple domains, including epidemiology, pathobiology, existing treatments, genetics, *“omics”, biomarkers, in vitro and in vivo model systems and data, etc., etc.
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You have experience with primary human immune cell activation assays using multparameter flow cytometry. You have experience with T cell cytotoxicity assays using endpoint flow cytometry measurements.
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Experience in flow cytometry, microbiology, PCR and ELISA testing is a plus. Demonstrate basic knowledge of the GXP cellular therapy product manufacturing, and program development and evaluation, as well as needs assessment and marketing of the programWorking knowledge of flow cytometry, molecular biology, and genetic engineering is a plus.
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The ideal candidate will have neuroscience research experience employing a variety of in vitro/in vivo electrophysiology techniques including traditional whole-cell patch-clamp, extracellular field potential recordings, and qEEG. Additional computational or programming experience is also required.
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Demonstrated experience in diverse molecular and biochemical laboratory techniques applied to cell characterization at molecular or genetic levels (immunofluorescence, flow cytometry, qPCR, RNA sequencing)Well organized, self-motivated, team oriented, ability to multitask with attention to detailExcellent communication and writing skillsProficient in computational analysis and coding pipelines (R Studio, Python, etc.
$101,500 a yearFull-timeExpandApply NowActive JobUpdated Today
vivo flow cytometry associate scientist jobs in Boston, MA
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