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Provide expert leadership across Process Development, overseeing both strategic and day-to-day activities in upstream and downstream process development of proteins. Note: This is a senior leadership role, and the candidate must exhibit exceptional strategic vision, leadership skills, and a proven track record of successful process development in the biopharmaceutical industry.
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Successfully provide technical guidance to customers during evaluation, process development scale-up and implementation of Purolite chromatography resins to cGMP.Work directly with end-users to understand purification goals and address challenges.
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Postgraduate training or equivalent experience in peptide synthesis, medicinal chemistry, protein engineering, and/or combinatorial chemistry. Design, validate and implement synthesis projects in organic synthesis, peptide synthesis, bioconjugation, purification, and characterization of compounds of interest.
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The primary focus for this position will be purification of recombinant proteins and nanoparticles using chromatography techniques while maintaining functional structure and native-like protein folding.
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Protein extraction, RNA extraction, PCR, qPCR, Elisa, Western Blot, Jess Automated Western Blot System, MSD. Strong knowledge of basic principles of protein extraction, RNA extraction, PCR, qPCR, Elisa, and automated Western Blot analysis using Jess system.
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Perform analytical testing to support cell line development, upstream and downstream process development, formulation development, process characterization studies, and stability studies.
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Bachelors 3+, with Masters 1+, or recent PhD graduate with experience in protein purification/analysis and chromatography/spectroscopy equipment. Review Master Batch Records for accuracy and trend process data supporting process development or fill/finish manufacturing operations.
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Experience with some scale-down/-up of biologics drug product process development activities; buffer preparations, testing using compendial methods (osmo, protein conc., pH, etc.
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Responsible for technology transfer of drug substance manufacturing process including fermentation and downstream purification to CDMO and external partners. Support drug product process development, manufacturing, and analytical development at CDMOs.
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The Director of Bioconjugation at Abzena Bristol site will be responsible for managing key client account programs, and overseeing key research, development and production operations related to antibody-drug conjugates, conjugated vaccines, oligonucleotide-protein conjugates, and other conjugated products.
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Primary job emphasis focusing on CHO cell line development and upstream bioreactor process development. Strong scientific background of recombinant protein expression, cell line development, cellular metabolism, and media optimization.
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A basic understanding of formulation and drug product process development for biologics (antibodies, fusion proteins, bi-specifics, vaccines, antibody drug conjugates, etc. good understanding / experience in biologics drug product process (freeze-thaw, filtration, mixing, filling, lyophilization.
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Our client, a global CDMO, is looking to add a Principal Scientist, Process Chemistry to their research and development team. As a member of process R&D, the qualified candidate will develop and execute a work plan for synthesis of a small molecule; then conduct hands on chemical process research and development, report results, and support GXP manufacturing of that molecule.
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A minimum of 6 years post-PhD or 10 years post-MS of industry experience in therapeutic protein formulation/analytical development. The successful candidate will have a proven record of experience that includes effective collaborations with process development/manufacturing sciences and research functions in biopharmaceutical industry setting.
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Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. This position will involve the investigation and development of algorithms that are robust in interpreting the many various features of mass spectrometry proteomics data.
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process development protein purification jobs Company: Abbvie in Not-specified, Alaska
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