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Role: seeking motivated, team-oriented individuals with expertise in protein purification process development to support our pre-pivotal purification & pilot operations group - an opportunity to work in teams for the early and late stage development of protein molecules.
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Experience with some scale-down/-up of biologics drug product process development activities; buffer preparations, testing using compendial methods (osmo, protein conc., pH, etc.
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Incyte Corporation is seeking a motivated and experienced protein purification scientist to provide technical expertise in monoclonal antibody (including bispecifics) purification process development, characterization, and validation primarily for novel therapeutic monoclonal antibody products throughout all stages of clinical trials and commercialization.
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Experience with process development, technology transfer, process validation, and cGMP bio-manufacturing are highly desired. Experience designing and performing process development/characterization experiments, using either One Factor At a Time (OFAT) or Design of Experiments (DOE) with software like JMP or Minitab, etc., approaches.
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Candidates will have a demonstrated record of excellent competency in laboratory research, with a focus on protein-related work, cell line development, and process development, and should have a strong understanding of mammalian cell biology, biochemistry and chemical biology, and immuno-oncology.
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A basic understanding of formulation and drug product process development for biologics (antibodies, fusion proteins, bi-specifics, vaccines, antibody drug conjugates, etc. Review Master Batch Records for accuracy and trend process data supporting process development or fill/finish manufacturing operations.
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Good understanding / experience in biologics drug product process (freeze-thaw, filtration, mixing, filling, lyophilization) Protein formulation/stability of various dosage forms (liquid/lyophilized) employing a variety of biochemical and biophysical analytical techniques, such as HPLC, capillary electrophoresis, and/or spectroscopy methods, analytical data analysis.
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Senior Scientist/Principal Scientist, Formulation & Process Development. Expertise and knowledge in process development, scale up of formulation production and purification unit operations and tech transfer activities.
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Job Title: Research Associate II – Downstream Process Development. Familiar with the downstream purification process, which includes centrifugation, chromatography, and filtration.
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Previous experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.
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We have up to two openings for an Academic Graduate Appointee participating in developing novel approaches and platforms in support of synthetic biology research emphasizing cell-free protein production methodologies and vaccine development.
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Hands-on protein biochemistry experience (e.g., characterizing and analyzing protein-ligand or protein-protein interactions) Collaborate within Discovery Science and cross-functionally with Compound Management, Structural Biology, and Biology/Chemistry teams to develop and implement biochemical and biophysical assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development.
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Provide expert leadership across Process Development, overseeing both strategic and day-to-day activities in upstream and downstream process development of proteins. Note: This is a senior leadership role, and the candidate must exhibit exceptional strategic vision, leadership skills, and a proven track record of successful process development in the biopharmaceutical industry.
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Successful candidate as a protein purification associate plays an integral role in the success of recombinant protein development and manufacturing. Perform protein purification methods on gravity or AKTA HPLC/ FPLC using affinity, ion exchange, hydrophobic, reverse-phase, and size exclusion chromatography.
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Protein extraction, RNA extraction, PCR, qPCR, Elisa, Western Blot, Jess Automated Western Blot System, MSD. Strong knowledge of basic principles of protein extraction, RNA extraction, PCR, qPCR, Elisa, and automated Western Blot analysis using Jess system.
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process development protein jobs Company: Abbvie in Not-specified, Alaska
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