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Perform cell culture, prepare cell slides or/and tissue sections, carry out immunofluorescence staining, microscopy, image processing, protein pull-down, protein measurement, and purification.
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Responsibilities will include protein purification from tissues and/or recombinant protein systems, investigating protein biochemistry, analyzing protein-protein interactions, and electron Cryo-microscopy studies of normal RyR and RyR with known disease mutations.
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The Senior Research Scientist II, Purification Process Development (Pre-Pivotal) will be responsible for leading purification development including process development and process implementation at internal or external GMP facilities for Gilead biologics entities during pre-pivotal phases development (pre-clinical, phase I/II.
$191,335 - $247,610ExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Experience with some scale-down/-up of biologics drug product process development activities; buffer preparations, testing using compendial methods (osmo, protein conc., pH, etc.
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The successful candidate should have experience in electron Cryo-microscopy and a successful track record in molecular biology/physiology. Columbia University Irving Medical Center’s Department of Physiology and Cellular Biophysics invites applicants for an exciting Assistant Professor research position.
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A basic understanding of formulation and drug product process development for biologics (antibodies, fusion proteins, bi-specifics, vaccines, antibody drug conjugates, etc. Review Master Batch Records for accuracy and trend process data supporting process development or fill/finish manufacturing operations.
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We are currently seeking a highly motivated and experienced Senior Scientist to join our Downstream Process Development group. Senior Scientist - Downstream Process Development.
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Lead the peptide API design, development, manufacturing, process optimization, and process validation of efficient and sustainable manufacturing processes for peptide synthesis and purification.
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A flexible scheduleTraining and CertificationsOne on one mentorshipWhat you’ll do:Position 1: Protein Biochemistry/Structural BiologyPerform assigned research duties including but not limited to:Expression, purification, and refolding of recombinant proteins from E.coli, yeast, cell cultures, and/or plants.
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Candidates with experience in tissue culture, protein expression, and purification are preferred. We are a protein engineering lab combining state-of-the-art computational protein design technologies with directed evolution methodologies.
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Hands-on protein biochemistry experience (e.g., characterizing and analyzing protein-ligand or protein-protein interactions) Collaborate within Discovery Science and cross-functionally with Compound Management, Structural Biology, and Biology/Chemistry teams to develop and implement biochemical and biophysical assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development.
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The Associate Scientist s expected to design, develop, and execute purification processes to meet early-stage process development objectives and timelines. BPD group is present in multiple sites including Gaithersburg, MD, and Cambridge UK. The Purification Process Sciences Group is accountable for purification and conjugation process development of complex biopharmaceuticals including proteins, monoclonal antibodies, antibody-drug conjugates, nucleic-acid based modalities, and vaccines.
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Provide expert leadership across Process Development, overseeing both strategic and day-to-day activities in upstream and downstream process development of proteins. Note: This is a senior leadership role, and the candidate must exhibit exceptional strategic vision, leadership skills, and a proven track record of successful process development in the biopharmaceutical industry.
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You have an understanding of protein expression and purification. You will drive the development of experimental designs for understanding protein and RNA interactions. Experience with RNA biochemistry, synthesis, purification, characterization, and structural evaluation with techniques including crystallography, SHAPE-MaP, or NMR is preferred.
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The position requires extensive experience in antibody-based therapeutics, protein engineering, molecular biology, purification, and characterization. scientific background in structural biology, molecular biology, biochemistry, protein purification and characterization.
$100,000 - $150,000 a yearFull-timeExpandApply NowActive JobUpdated Today
process development protein purification jobs Company: Abbvie in Not-specified, Alaska
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