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Good familiarity with antibody repertoire analysis- NGS data handling and analysis from either in vivo or in vitro sources. Excellent experience of in vivo immunization strategies and handling antibody discovery platforms, specifically single B cell cloning, with adeptness in FACS based sorting strategies.
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You will be responsible for the development and execution of short and long-term medical plans supporting ex vivo cell therapy programs in both immuno-oncology and autoimmunity and aligning them with overall business goals.
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Collaborate with CRO and academic partners; employ cutting-edge in vitro and in vivo animal and human models to advance drug discovery and development programs up to and including IND filing.
$250ExpandUpdated 10 days ago - UpvoteDownvoteShare Job
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Experience with in vivo cell therapy and/or virus like particle (VLP) application is preferred. Apply methods in cell biology, mammalian cell culture, molecular biology, and biochemistry to advance scientific projects.
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At least 1 first-author publication (published or manuscripts submitted for publication) in high-quality specialty or general readership journalsExperience in in vivo disease models, tissue harvesting, dissociation, and cell isolation.
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Proficiency in in vitro transcription/translation systems and in vivo cell based reporter assays. You are familiar with how RNA secondary structure and topology affects both its generation (in vitro or in vivo) and its function.
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Our portfolio, spanning from in-vitro and in-vivo diagnostics to image-guided therapy and innovative cancer care, is crucial for clinical decision-making and treatment pathways. PhD in mechanical engineering or mechatronics or closely related fields (preferably with research background in the field of medical device.
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Experience with multiple antibody discovery platforms including in vivo immunization and in vitro display approaches. Oversee CROs to produce recombinant proteins and antibodies for in vitro screening and scale-up for in vivo studies, manage in-house inventory, help build LIMS and lab as company grows.
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At Siemens Healthineers, we pioneer breakthroughs in healthcare. You have demonstrated analytical skills with proficiency in analytical tools such as MATLAB/Simulink and Spice. You are highly proficient in the use of electrical CAD tools, Altium preferred.
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The successful candidate will join a dynamic, multi-disciplinary team and play a key role in developing and applying in vivo models to evaluate novel cancer therapies in the early-stage drug discovery pipeline.
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S/he will also be collaborating closely with the internal research team (discovery biology to in vivo pharmacology) to integrate translational medicine into development and clinical strategies.
$200ExpandUpdated 10 days ago - UpvoteDownvoteShare Job
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We deploy multidisciplinary approaches spanning chemistry, biochemistry, proteomics, structural biology, cancer biology, and in vivo studies to dissect and target the oncogenic pathways of interest.
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Performing in vivo catheterizations for measurement of vascular and chamber pressure in cardiovascular rodent models. Communicating, collaborating and consulting with veterinarians, peers and scientific investigators on best practice, optimization and production of in vivo, surgical models.
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Design and develop in-vivo/in-vitro research plans and pharmacology studies to enable identification of clinical candidates. This individual will play a critical role in the design, development, and execution of in-vivo and in-vitro studies to screen various biologic platforms, including monoclonal antibodies, to identify leads with desired pharmacological properties in support of candidate nomination and envisioned target product profile.
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PRINCIPAL DUTIES AND RESPONSIBILITIE: The project will focus on the design, synthesis, and evaluation of novel lipid and polymer libraries to be incorporated into nanoparticles for in vivo and organ-on-a-chip settings to decode the chemical and biological features dictating efficacy and successful delivery of gene therapies.
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in vivo jobs in Boston, MA
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