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Biocytogen Boston in vivo Team is seeking a talented, enthusiastic, highly motivated in vivo Pharmacologist to execute relevant disease models to support preclinical research services for biotech or pharma companies.
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Experience and interest in assay development (in vitro/ex vivo/in vivo) Design screening funnels that integrate our novel mDesign in vivo biologics design platform.
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Skills: HPLC, SOP, In Vitro, In Vivo, Protein Purification, GMP (Good Manufacturing Practice) The purification group is responsible for non-GMP protein- drug lead generation, supporting the various company research units and their pre-clinical therapeutic in- vitro and in- vivo needs.
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Understanding of ex-vivo cell-characterization by multi-color FACS and cytokine profiling (ELISA/MSD/Luminex), and gene expression analysis (qPCR, RNAseq). Conduct detailed in vitro characterization and testing of cell therapy products using protein and gene expression analysis.
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Develop RNA purification, characterization, and analytical methods to generate therapeutic grade material for in vitro and in vivo studies. The ABC site, based in Worcester, MA, offers a unique setting where GM, Biologics drug discovery, development and manufacturing coexist in one location.
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Perform circRNA and mRNA purifications to support chromatography process development and the supply of 1 mg of material to support in-vivo mouse studies and aid in the development and supply of the 1 gram scale.
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In addition, the CBU houses, operates, and manages the HNRCA rodent behavior and in vivo imaging core. Must be able to work under conditions that includes animal odors, heat and humidity from cage washing rooms, and biohazardous materials and chemicals used in research.
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You can learn more about us by visiting DescriptionWe are looking for a CTO/CSO, RNA Delivery System (LNP) with a proven track record in biochemical engineering and nanomedicine to lead the development of novel delivery systems for different technology platforms, including mRNA vaccines, therapeutics, siRNA, and in vivo gene editing.
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Work will consist of instrumentation development and the performance of Raman arthroscopy measurements in a series of ex vivo and in vivo model systems to assess the diagnostic capability of the platform.
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This is a unique opportunity to work with world-class technologists innovating in cutting edge molecular biology and compute approaches to realize the potential of a novel protein engineering platform.
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Design and conduct experiments to support new target validation, analysis and interpretation of results, with focus on in vitro and retinal in vivo assays/models to support discovery and translational drug development programs.
$104,000 - $166,750 a yearFull-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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Postdoctoral Research Fellowships (In-vivo Microscopy) Demonstrated excellence in one of the various forms of optical coherence tomography, confocal microscopy, or other in vivo microscopy techniques is required.
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Will optimize lipid nanoparticle formulations for in-vitro and ex-vivo experiments; maintain cell lines and perform cell-based assays; be responsible for in-vivo work such as intravenous, intramuscular, intranasal, and subcutaneous injections of mRNLNPs to mice/rats, organ harvesting, blood collection, ELISA, and imaging techniques; and assist in lipid synthesis and experimental studies in mice/rats aimed at understanding the delivery of nucleic acids.
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You will be responsible for the development and execution of short and long-term medical plans supporting ex vivo cell therapy programs in both immuno-oncology and autoimmunity and aligning them with overall business goals.
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Conduct formulation and/or process screening to improve biophysical characteristics and in vivo gene editing in animal models. The Scientist will work on developing safe and potent delivery systems to enable in vivo gene editing.
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in vivo jobs in Cambridge, MA
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