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Thorough working knowledge of in vivo techniques and animal model used in a biopharmaceutical R&D setting, including familiarity with various therapeutic modalities such as small molecule therapeutics, cell therapy, and gene therapy.
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Potentially in vivo evaluation of the sensitivity of different lung cancer models to targeted therapies, including establishment of tumor xenografts, drug treatment, assessment of tumor response and harvesting of tumor tissue.
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The candidate is expected to participate in in vivo non-human primate protocols. PRINCIPAL DUTIES AND RESPONSIBILITIES: Provide clinical support services at the Center for Transplantation Sciences (CTS), including post-procedural recovery, restraint, and drug treatments of in vivo subjects as needed.
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Will join a group of multidisciplinary researchers performing cutting-edge research focused on cancer nanomedicine within the larger community of KI drug delivery researchers; and provide experimental and logistical support for multiple projects related to cancer nanotechnology using techniques ranging from nanomaterials synthesis and characterization to in vivo studies.
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We are recruiting a Scientist II/Sr. Scientist I with experience in phase-appropriate analytical method development, optimization, and qualification of physicochemical assays for lot release, stability, and characterization of cell and gene therapy products to support Beam's in vivo programs using lipid nanoparticle (LNP) delivery.
ExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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The projects will have a dual focus on performing in vitro mechanistic studies in triple negative breast cancer cell lines and in vivo studies using mouse models of triple negative breast cancer.
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This includes hands-on experience in vitro cell-based assays, flow cytometry, and/or in vivo studies, This may be exemplified by a productive PhD or postdoc and/or industry experience. This includes procuring reagents, validating protocols, and standardizing workflows related to mammalian cell culture, in vitro functional and phenotypic assays, and in vivo experimental design and planning.
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Collaborate closely with other groups within the early CVRM therapeutic area to provide expert clinical input into pre-clinical scientific activities such as target selection, lead generation and optimization, clinical pharmacology, in vivo animal studies, in vitro studies, and drug formulation and manufacturing.
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We are a diverse team of experienced physicians and clinical scientists who collaborate to delineate early phase clinical development strategies, design innovative phase I-IIb clinical trials, develop and validate novel surrogate endpoints, and translate scientific ideas to proof of concept studies in targeted patient populations.
Full-timeExpandApply NowActive JobUpdated 21 days ago - UpvoteDownvoteShare Job
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Experience with the designing and performing assays for non-Standard Amino Acid proteins in in vitro or in vivo. Strong understanding of fundamental concepts in protein therapeutics and in vivo delivery preferred.
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The group supports non-GMP transient protein lead production across the companies diverse biotherapeutic discovery portfolio to enable the research units and their pre-clinical therapeutic in-vitro and in-vivo needs.
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The ideal candidate will be contributing towards in vitro / in vivo BA and biomarker (BM) quantitation studies along the drug discovery path using cell-culture, quantitative bioanalysis and related lab skills, especially for early-stage programs in the company portfolio.
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The purification group is responsible for non-GMP protein- drug lead generation, supporting the various research units and their pre-clinical therapeutic in- vitro and in- vivo needs. The purification group is responsible for non-GMP protein- drug lead generation, supporting the various research units and their pre-clinical therapeutic in- vitro and in- vivo needs.
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A successful candidate will have had experience with preclinical drug discovery including immunoassays, flow cytometry, cell cytotoxicity assays, and ex vivo cell-based assays. A successful candidate will have had experience with preclinical drug discovery including immunoassays, flow cytometry, cell cytotoxicity assays, and ex vivo cell-based assays.
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Basic in vivo skills (rodents) and comfortable performing bone marrow preps (rodent, NHP, human). Molecular biology skills such as PCR, qPCR/ddPCR, Western blotting, ELISA. Perform cell culture with rodent, primate, and human primary cells, as well as relevant cell lines.
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vivo job in Boston, MA
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