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Responsible for documentation of laboratory animal histories and in vivo study data, IACUC protocol awareness, animal handling with multiple species and study types, dosing, necropsy, blood collection, etc.
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Strong in vivo skills- mouse handling, tumor implantation (sq, orthotopic), drug administration (IP, SQ, IV, PO), blood collection & necropsy. We are seeking a highly motivated, in vivo-based scientist with a background in cancer immunology.
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Background in lab animal (in vivo) research is a must. This position requires a broad knowledge of animal anatomy, physiology, and surgery to help develop and support in vivo models to screen therapeutics and devices being developed for various indications.
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Participate in planning, design, execution, and analysis of in vivo pharmacology experiments to assess compound efficacy, safety, and PK/PD profiles. Hands-on experience with design and execution of complex in vivo experiments utilizing CDX/PDX tumor models.
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As a postdoctoral researcher at the Center for Embryonic Cell and Gene Therapy of Oregon Health & Science University, this position will work in the area of gene therapy on development of various genome editing approaches and their delivery into target cells and tissues in vitro (human) and in vivo (mouse.
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Familiarity with in vivo neuro-electrophysiology and optical methods to investigate the brain or other nervous systems. The key technical pillars include in vivo large-scale electrophysiology and electrical stimulations using ultra-flexible indwelling electrodes, two-photon imaging, and behavioral paradigms.
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The Nuclear Measurements and Analytical Services Group is responsible for maintaining Department of Energy Laboratory Accreditation Program (DOELAP) accreditation for in vivo and in vitro analytical programs and providing specialty measurement capabilities as an essential part of the ORNL Radiological Protection Program.
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Please include a cover letter when you applyScientific lead for in vivo pharmacology, PK/BD and toxicology studies. Qualifications, Education & ExperiencePhD in Pharmacology, Oncology, Pharmaceutical Sciences, Toxicology or a related discipline with a minimum of 5 years relevant experience or an equivalent combination of industry experience in preclinical drug discovery and developmentSkills & AbilitiesDemonstrated advanced knowledge and hands-on experience in relevant in vivo oncology/pharmacology models.
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The successful candidate will interact with a dynamic team of scientists to conduct oncology and pharmacological studies in vitro, ex vivo, and in vivo efficacy models. Experience with a wide range of in vitro cellular and biochemical assays such as cell culture, western blotting, immunofluorescence staining, flow cytometry.
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Experience with a broad range of materials and cargoes used for nucleic acid deliveryExperience with in vivo experiments assessing biodistribution and reporter assays such as IVIS imaging, RNA scope, nanoimager etc.
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Apply molecular/biochemical assays to ex vivo and in vivo studies as needed. As a Senior Associate Scientist - Molecular Biology, you will participate primarily in the generation and evaluation of novel transgene constructs, and the development and application of cell-based in vitro assays to evaluate performance of the constructs.
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Our Alloy Discovery Services (ADS) team is looking for a Scientist/Senior Scientist to join our in-vivo antibody discovery team in Waltham, Massachusetts. This role will report to Head of In-Vivo Antibody Discovery with autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy.
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Cambridge, MA.Internal Title: Principal Scientist I/II#LI-OnsiteAbout the role:The successful candidate will join a dynamic, multi-disciplinary team and play a key role in developing and applying in vivo models to evaluate novel cancer therapies in the early-stage drug discovery pipeline.
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Performs independently routine downstream analyses for in vivo studies (e.g., microbiological plating, ELISA, etc.) Assists with in vivo studies, including intravenous injection, intraperitoneal injection, intravaginal inoculation, vaginal lavage, tissue collection, anesthesia administration, and animal imaging.
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Responsible for designing and carrying out a variety of in vitro and in vivo experiments leading to cancer immunology target validation and development of therapeutic antibodies. Experience in tissue culture and cell-based assays and flow cytometry is a plus.
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