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Good familiarity with antibody repertoire analysis- NGS data handling and analysis from either in vivo or in vitro sources. Excellent experience of in vivo immunization strategies and handling antibody discovery platforms, specifically single B cell cloning, with adeptness in FACS based sorting strategies.
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Optimize and perform studies to define target biology in mouse models of inflammation and immunity for in vivo in vitro and ex vivo applications. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds.
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The Roehrl Lab at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School in Boston has an immediate postdoc opening (PhD, MD/PhD, or MD) for motivated individuals with strong backgrounds in cell/cancer biology, immunology, stem cell biology, biochemistry, disease models (cell culture, organoids, xenografts, or animal models), proteomics (mass spectrometry)/genomics, and/or informatics.
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Oversee generation, screening, and validation of antibody candidates using in vitro and in vivo assays. Job Description: As a Principal Scientist, Antibody Development, you will play a pivotal role in driving our antibody discovery programs from conception through to preclinical development.
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Our ex vivo autologous gene therapy approach harnesses the power of genetically modified blood stem cells and seeks to correct the underlying cause of disease in a single administration.
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Collaborate closely with cross-functional teams and effectively communicate delivery timelines to different stakeholders (in vitro biology, in vivo pharmacology) to ensure efficient transfer of materials.
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Performing in vivo catheterizations for measurement of vascular and chamber pressure in cardiovascular rodent models. Communicating, collaborating and consulting with veterinarians, peers and scientific investigators on best practice, optimization and production of in vivo, surgical models.
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Relevant experience with T cells and other immune cells in vitro and in vivo, immunological techniques and multicolor flow cytometry are highly desirable. Qualifications Candidates with a recent PhD or MD/PhD in immunology and experience in murine and/or T-cell immunology, molecular biology and in vivo modeling are encouraged to apply.
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Position SummaryThis position is a key leadership role for the development of the In Vivo franchise at CRISPR. Reporting to the Senior Director of Regulatory Affairs CMC, you will work closely with cross-functional teams and partners to bring multiple novel therapies to patients.
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Experiments include in vivo assays, DNA/RNA/protein isolation and quantification including molecular biology techniques such as Gel Electrophoresis, qPCR, Western blot, and ELISA, tissue culture, microscopy, and various immunological assays.
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Designing and implementing translational experiments involving in vitro, ex-vivo and in vivo studies in collaboration with others including preclinical pharmacologists, biomarker scientists and biologists.
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Generate and utilize state-of-the-art cellular and animal models of disease to support RNA exon editor efficacy testing Oversee key decision making in vitro and in vivo non-clinical experiments to understand the therapeutic potential of novel RNA exon editing technologies.
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Job Title: Associate Scientist/Scientist, In Vivo Pharmacology. We are seeking a highly motivated individual to join our In-Vivo pharmacology program, this role focus on early drug discovery and technology development.
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Understanding of in vitro/vivo antibody discovery platforms and knowledge of downstream CMC development is essential for success. PhD in Biochemistry, Chemistry, Molecular Biology, Chemical Engineering, or related field with minimum of 10 years of relevant technical and leadership experience or a M.S. and B.S. with 15 years of relevant experience within a pharmaceutical or biotechnology environment.
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Spectral Instruments Imaging, a member of the Bruker BioSpin Preclinical Imaging Division, is a fast-growing life science company with a robust history of producing superior in vivo imaging systems.
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in vivo jobs in Boston, Mills, Wyoming
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