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Perform cell-based studies to support identification/validation/differentiation of small molecule protein degraders, implementing of a wide variety of laboratory techniques: mammalian cell culture, Western blotting, cell-based genetic engineering (lentiviral, CRISPR, RNAi), flow cytometry, etc.
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Excellent skills with cell culture such as primary cell culture, stable and transient protein expression, fixed and live cell imaging by IHC or immunofluorescence, flow cytometry.
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Benefits include Associate discount; 401(k) match; medical/dental/vision; HSA; health care FSA; life insurance; short/long-term disability; paid holidays/vacation /sick/bereavement/parental leave; EAP; incentive programs for management; auto/home insurance discounts; tuition reimbursement; scholarship program; adoption/surrogacy assistance; smoking cessation; child care/cell phone discounts; pet/legal insurance; credit union; referral bonuses.
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The Role: We’re seeking a highly motivated Senior Research Associate or Scientist with a strong background in molecular and cellular biology and cell culture to join our team and contribute to building our pipeline.
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The position aims for candidates with a strong quantitative and computational background with extensive experience in genomics/transcriptomics (analysis of different bulk/single cell/spatial Next Generation sequencing Techniques as well as development of novel methods.
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Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFomeTM was developed in Professor George Church’s lab, a pioneer in synthetic biology, and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency and speed.
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The ideal candidate will have a background in cellular biology, molecular biology, and bioinformatics, with a strong focus on single-cell techniques. We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis, a newly discovered form of programmed cell death.
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Experience with human stem cell culture, genetic/genomic manipulations (CRISPR), biochemical assays, and automation applied to high throughput screening approaches are needed. Their group utilizes genetic (CRISPR) and pharmacological manipulations of induced pluripotent stem cell (iPSC) model systems to validate the role of targets in mechanisms related to pathobiology of human diseases.
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The Scientist will have a strong background in iPSC and/or human embryonic stem cell derivation and maintenance, neurodevelopment, 3D neuronal models, and familiarity with general editing techniques is a plus.
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As a Senior Specialist, Materials Planning and Logistics, Cell Therapies, you will support the routine operations of the cell therapy team and report to the Senior Manager of Manufacturing Supply Operations at Takeda's clinical cell processing facility in Cambridge, Massachusetts.
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Familiarity with common molecular and cell biology techniques to support ligand characterization (e.g., western blotting, cell culture, assay development, in vitro viability assays) Strong background in chemical biology techniques applied to target engagement and functional characterization of ligands in cellular assays.
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The researcher will endeavor to solve some of the biggest problems in the field, using cutting-edge technologies and concepts, e.g. CRISPR gene editing, stem cell technology, human brain organoids, genetically engineered mouse models, gene therapy, synthetic biology, directed evolution and protein engineering, etc.
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Working knowledge of protein biochemistry and familiarity with cell culture procedures Additional Information Why Biogen? Who You Are You are a recent Ph. D. graduate with a background in chemical biology, proteomics, chemistry, or biochemistry who is self-motivated and eager to make impactful contributions to drug discovery.
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We are seeking a Principal or Distinguished Scientist specializing in cotton fiber development to guide our efforts in isolating, cultivating, and optimizing stable plant stem cell lines for fiber production.
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The TCW laboratory ( in the Department of Pharmacology, Physiology & Biophysics at Boston University Chobanian & Avedisian School of Medicine in Boston, Massachusetts is looking for highly motivated and skilled molecular and cellular biologists or stem cell biologists to be the drivers of our efforts to translate the genetics of human AD toward therapeutic interventions.
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