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Strong subject matter expertise in immune-oncology, cell therapy drug discovery and development including CMC considerations, CAR design, engineering and armoring strategies, innate immune cells such as NK and gamma delta for the purposes of leading drug development projects from start to the clinic.
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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.
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Work closely with CROs and discovery DMPK to generate high quality data. Must have cultivated an appropriate attitude to deal with the challenges of drug development and experienced in regulatory interactions.
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As a Senior Scientist within the Research Analytics team you will help provide analytics solutions to inform compound discovery and prioritization for our early drug discovery platforms.
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Expertise in establishing binding assays for protein/protein or protein/small molecule interactions by SPR, DSF, ITC and/or MST and have applied these to small molecule drug discovery. You will be a Biophysics lead on projects and play a key role in drug discovery.
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We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis.
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Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Communication, Curiosity, Data, Data Analysis, Design of Experiments (DOE), Detail-Oriented, Drug Development, Drug Discovery Process, Ethics, Gene Therapy, Group Problem Solving, Immunology, Inventory Management, Laboratory, Large Group Presentations, Leading Project Teams, Life Science, Machine Learning (Ml), Medical Research {+ 9 more.
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Qualified candidates must have a PhD in synthetic/organic chemistry or related scientific field with 15+ years’ experience in drug substance development and manufacturing and a proven track record in developing and scaling up chemical process to kilo lab, pilot plant and commercial plant scales.
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Possessing in-depth knowledge of antibody-based discovery, optimization/ engineering using in vivo based discovery methods that include transgenic animals/ llamas and single B cell cloning methodologies and NGS to manipulate and mine antibody populations appropriately for therapeutic antibody workflows.
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This is a unique opportunity for a PhD-level biologist to be involved in high-impact drug discovery projects in the newly developed Center for Therapeutic Discovery at Dana-Farber Cancer Institute.
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A Senior Associate Scientist is responsible for organizing, conducting, and reporting non-GLP rodent toxicology, investigative, and pharmacokinetics/toxicokinetics (PK/TK) studies that support drug discovery and development.
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Responsibilities Support the development of the Drug Substance strategy and oversee manufacturing of preclinical and clinical material. Senior Director, Drug Substance Position Summary Reporting to the VP, Head of CMC Development, the Senior Director, Drug Substance will be responsible for leading the drug substance team in development and manufacturing as part of PepGen ́s CMC team.
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Plan, design and execute in-vivo pharmacological experiments to support and advance drug discovery programs in immunology and oncology. Effectively collaborate with integrated teams in a matrix organization setting to facilitate the conduct of studies and to the success of discovery programs.
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Our group utilizes innovative genomic technologies (i.e., pooled, and arrayed CRISPR screening, Optical Pooled Screening, Spatial Tx), and multi-omics approaches such as Perturb-Seq to impact all stages of the drug development pipeline from pre-clinical to clinical development.
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Expertise and hands-on experience with protein purification methods used in discovery and process development. Execute hands-on lab work to express, purify, and characterize novel protein therapeutics to support antibody screening and lead optimization in discovery programs.
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drug discovery jobs Title: doctoral in Malden, MA
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