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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.
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We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis.
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Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Communication, Curiosity, Data, Data Analysis, Design of Experiments (DOE), Detail-Oriented, Drug Development, Drug Discovery Process, Ethics, Gene Therapy, Group Problem Solving, Immunology, Inventory Management, Laboratory, Large Group Presentations, Leading Project Teams, Life Science, Machine Learning (Ml), Medical Research {+ 9 more.
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Qualified candidates must have a PhD in synthetic/organic chemistry or related scientific field with 15+ years’ experience in drug substance development and manufacturing and a proven track record in developing and scaling up chemical process to kilo lab, pilot plant and commercial plant scales.
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This is a unique opportunity for a PhD-level biologist to be involved in high-impact drug discovery projects in the newly developed Center for Therapeutic Discovery at Dana-Farber Cancer Institute.
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Provide scientific direction and pathology expertise to project specific IHC, ISH and spatial endpoints in collaboration with the DSRE Investigative Pathology and Toxicology labs, DMPK, and Drug Discovery Unit translational pathology groups.
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Responsibilities Support the development of the Drug Substance strategy and oversee manufacturing of preclinical and clinical material. Senior Director, Drug Substance Position Summary Reporting to the VP, Head of CMC Development, the Senior Director, Drug Substance will be responsible for leading the drug substance team in development and manufacturing as part of PepGen ́s CMC team.
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The Hematology group in the Internal Medicine Research Unit (IMRU) is seeking a highly motivated BA/BS scientist with in vivo pharmacology experience to support preclinical drug discovery efforts for Hematology programs.
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As a Scientist II/Sr. Scientist I at NextRNA Therapeutics, you will join an interdisciplinary team of highly creative and talented individuals whose vision is to improve patients’ lives by expanding the space of small molecules targeting RNA. You will have an opportunity to work with a diverse team of biologists, biochemists, chemists, and computational biologists to support drug discovery programs for the next wave of RNA therapeutics.
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By integrating our propriety screening technology using the body’s natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently identify novel, biologically relevant allosteric sites for protein or RNA targets, and rapidly advance structural insights into small molecule therapeutics design.
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Possessing in-depth knowledge of antibody-based discovery, optimization/ engineering using in vivo based discovery methods that include transgenic animals/ llamas and single B cell cloning methodologies and NGS to manipulate and mine antibody populations appropriately for therapeutic antibody workflows.
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The Research Associate I, Downstream CMC (Contract) position will support the Company’s intracellular biologics discovery programs. They will work closely with downstream and upstream teams to progress discovery and development programs.
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Alloy’s Translational Research team supports our drug discovery partners with in vitro and in vivo testing of therapeutic drug candidates across multiple modalities. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.
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The RoleAs a Lab Technician, Bioanalytical, you will work with our Antibody Discovery Services team to support the discovery of antibody-based therapeutics. MAY THE BEST DRUG WIN.Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication.
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This position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of mechanistic research, drug discovery, and preclinical drug development.
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drug discovery jobs Title: doctoral in Cambridge, MA
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