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Strong subject matter expertise in immune-oncology, cell therapy drug discovery and development including CMC considerations, CAR design, engineering and armoring strategies, innate immune cells such as NK and gamma delta for the purposes of leading drug development projects from start to the clinic.
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Must have cultivated an appropriate attitude to deal with the challenges of drug development and experienced in regulatory interactions. Familiarity with DMPK assays (e.g. enzyme inhibition, induction, metabolite identification, MIST analysis, transporter assays etc.
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Responsibilities Support the development of the Drug Substance strategy and oversee manufacturing of preclinical and clinical material. Senior Director, Drug Substance Position Summary Reporting to the VP, Head of CMC Development, the Senior Director, Drug Substance will be responsible for leading the drug substance team in development and manufacturing as part of PepGen ́s CMC team.
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Qualified candidates must have a PhD in synthetic/organic chemistry or related scientific field with 15+ years’ experience in drug substance development and manufacturing and a proven track record in developing and scaling up chemical process to kilo lab, pilot plant and commercial plant scales.
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Expertise in establishing binding assays for protein/protein or protein/small molecule interactions by SPR, DSF, ITC and/or MST and have applied these to small molecule drug discovery. You will be a Biophysics lead on projects and play a key role in drug discovery.
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Demonstrated track record of accomplishments, publications and conference presentations in computational chemistry and drug discovery. The successful candidate will play a leading role in developing medicinal chemistry optimization strategies for our most important drug discovery campaigns.
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Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Communication, Curiosity, Data, Data Analysis, Design of Experiments (DOE), Detail-Oriented, Drug Development, Drug Discovery Process, Ethics, Gene Therapy, Group Problem Solving, Immunology, Inventory Management, Laboratory, Large Group Presentations, Leading Project Teams, Life Science, Machine Learning (Ml), Medical Research {+ 9 more.
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Proven track record of planning and managing complex programs in early and/or late phase drug development with solid understanding of disease area and drug development pathway with the ability to facilitate and contribute to strategic discussions.
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We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis.
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The Senior Scientist / Principal Scientist will be able to follow programs as they proceed through development as supporting the overall drug substance development and manufacturing activities.
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Experience advising on statutes, regulations, and guidance documents applicable to market access activities, including Medicaid, 340B program, Veterans Administration, federal and state anti-kickback statutes, state drug pricing transparency laws, OIG guidance documents and advisory opinions, the False Claims Act, and the PhRMA Code.
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As a Senior Scientist within the Research Analytics team you will help provide analytics solutions to inform compound discovery and prioritization for our early drug discovery platforms. Within DSA, the Research Analytics team is driven by answering scientific questions during drug candidate discovery.
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Link to register: Instructions from the Drug & Alcohol Clearinghouse, Federal Motor Carrier Safety Administration (FMCSA): Keywords: CDL A, CDL B, driver, commercial driver's license, building products, job site, building materials, distributor, distribution, touch freight, load, unload, commercial vehicle and delivery.
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The Infusion Pharmacist II is responsible for the optimization of drug therapy by identifying, resolving, and preventing drug-related problems and adverse drug events. Ability to utilize references and/or drug information sources.
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A Senior Associate Scientist is responsible for organizing, conducting, and reporting non-GLP rodent toxicology, investigative, and pharmacokinetics/toxicokinetics (PK/TK) studies that support drug discovery and development.
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drug job Title: doctoral in Malden, MA
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