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Moderna’s Bioanalytics group is seeking an Associate Director with strong hands-on experience in ligand-binding assays, including pharmacokinetics (PK), pharmacodynamics (PD), and anti-drug antibody (ADA) assessments, to quantify mRNAs, proteins, and antibodies against therapeutic proteins.
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The ideal candidate will have strong antibody discovery knowledge and direct (or indirect) biologics-based therapeutic drug development experience. Therapeutic antibody drug discovery expertise, ideally utilizing single cell workflows.
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Perform serologic, molecular, and immunologic procedures that may include, but are not limited to, DNA extraction, PCR amplification, sequence-based typing, STR analysis, probe hybridization/detection, cytotoxic crossmatching, antibody screening/identification by Luminex and/or ELISA assays, and other procedures as defined.
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Proficiency in a variety of bioanalytical techniques including, but not limited to, ELISA, MSD, HTRF, flow cytometry, qPCR, NGS, mass spectrometry, and cellular imaging techniques. Prior industry experience in drug discovery or preclinical development is required, and focus on immunology, metabolism and antibody development is required.
ExpandApply NowActive JobUpdated 7 days ago - UpvoteDownvoteShare Job
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Provide assistance in the execution of experiments and analytical procedures including: molecular biology, DNA cloning, cell culture, protein production, ELISA, Biolayer interferometry and HPLC.
$78,000 - $83,500 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The (Sr) Research Associate/Associate Scientist will join efforts of Antibody Discovery, Protein Engineering and Process Development team to develop safe and effective T-cell engager therapies.
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Visterra, Inc., is seeking a highly motivated Research Associate with research experience in biochemistry, cellular and/or molecular biology to help discover and develop biologic therapeutics, as well as expand platform technologies that support our antibody-based drug discovery programs.
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Proficiency with biochemical and biophysical techniques like SPR, BLI, ELISA, DSF, DLS, etc., for protein ligand characterization, highlighting a comprehensive skillset in protein analysis. Perform thorough biochemical and biophysical characterization assays of antibody ligands to aid in the development of effective bioconjugation strategies.
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Your previous hands-on experience with manual and automated laboratory assays for screening and characterization of antibodies and biologics (e.g., ELISA, AlphaLisa, TR-Fret, Biacore, Octet, fluorescence/luminescence-based, flow cytometry) is highly desired.
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Validate antibody performance using WB, IHC, ICC, FC, IP, Elisa, and IgG concentration at the QC stage for Reagent projects. Validate antibody performance using sandwich ELISA at the QC stage for kit pair antibody projects.
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Experience with protein assays, e.g. production, purification, QC, Chromatography (Affinity, Size, Ionic etc) and detection (PAGE/ELISA/Blots), etc. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics.
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Expertise in antibody functional assays (ELISA, Octet, neutralization), biophysical characterization and molecular biology are required. Collaborate with the structural biology and computational teams to elucidate antibody activity and mode of action.
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Participate in the construction and screening of immune-based libraries through immunization, antibody display, and flow cytometry. Develop an understanding of fundamental principles, theories, and concepts in antibody-based drug discovery.
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Additionally, experience in developing biologics such as monoclonal antibodies and other complex antibody modalities, as well as experience in metabolic, autoimmune, and/or immunologic disease areas is required.
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We are looking for a talented Scientist to support the discovery and validation of our antibody brain shuttles and to lead the development of our brain shuttle-mediated oligonucleotide platform.
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elisa antibody jobs in Cambridge, MA
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