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As a CLS/CGMBS at Inocras, you will be performing clinical laboratory testing for a whole genome Next Generation Sequencing (NGS) assay in order to provide doctors and patients complete genetic profiles for cancer and rare diseases.
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Collaborating with tech transfer team to ensure successful hand-off of assay, reagent scale-up and QC processes. They will be core collaborators as part of the Assay Development team with full cross-disciplinary team of system integration engineers, algorithm developers and technical operations engineers to ensure V&V studies meet requirements.
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Experience with experimental design& planning, assay development, statistics, DOE techniques, data analysis methods and software (JMP, Python, or Matlab preferred). Experience with experimental design& planning, assay development, statistics, DOE techniques, data analysis methods and software (JMP, Python, or Matlab preferred.
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The incumbent will be responsible for drug screening, cell-based assay development, and biomarker discovery. Perform cell biology and molecular biology including primary and tumor cell culture, lentiviral transductions, RNA and protein preparation from cells and tissue, RT-PCR, western blotting, and ELISA. Some training may be provided.
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Prior experience must include: Understand chemistry and biology to analyze data and discuss with other researchers to plan strategies for drug discovery projects; independently design and implement scientific research projects relating to the development of oligonucleotide therapeutics; perform and direct synthesis of organic molecules, including chemically modified oligonucleotides; plan assay designs and manage technicians, including both in-house and external CROs to execute them.
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Determines appropriate assays and vendors for clinical biomarkers, and manages outsourcing of biomarker assay development and validation partnering with Translational Sciences colleagues when applicable.
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Independently manage molecular cloning experiments and assay development to construct DNA constructs and perform functional characterizations in microbial and plant systems. Knowledge of gene editing and analytical chemistry (e.g., GC, HPLC) is favorable, along with a background in protein interaction assays.
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Deep understanding of in vitro assays and assay development. Support assay design, optimization, validation, and data analyses. Strong background in designing and conducting multi-color flow cytometry, as well as analyzing FACS-based experiments.
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Understanding of NGS technology and assay development. Alida Biosciences is seeking a talented computational scientist with leadership ambition to join our team in its mission to transform omics with next-generation technologies.
$150,000 - $210,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Human whole blood, primary human and mouse/rat leukocyte isolation, cellular activation and differentiation, cytokine assays (MSD, ELISA), confocal/image-related techniques, etc. Familiarity with Client FACS and Spectral flow cytometry.
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Working in a team setting, the Research Scientist I, will primarily be involved in Research and Development projects serving as a technical lead in translating research ideas and concepts into the product development pipeline towards development of diagnostic assay products.
$93,000 - $149,000 a yearExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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Experience in cell culture and cell-based assay development, T-cell biology, and flow cytometry is helpful but not required. Our preclinical pipeline extends beyond to biologics against novel immuno-oncology targets, antibody-drug conjugates, bispecific and trispecific antibodies, and small molecules expected to reach the clinic in 6-24 months, underscoring our bench-to-bedside approach.
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Experience with super-resolution imaging techniques, microscopy, cell sorting, antibody based assays, biological sample preparation, image acquisition and data analysis, and/or cell based assay development.
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Skillsets of interest include expertise in tissue culture, biochemical tools (SDS-PAGE, immunoblotting, ELISA, protein assay), and a good working knowledge of molecular techniques including generation of mutant plasmids, transfection with plasmids/siRNA for transient protein expression in cell-based reporter systems as well as use of CRISPR and transcriptomics/proteomics technologies.
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Hologic is seeking a Sr. Manager, PMO who will be dedicated to program management of new assay development and instrumentation/engineering project and programs. Experience running programs that included assay development and validation.
$144,000 - $175,400 a yearExpandApply NowActive JobUpdated Today
assay job in San Diego, CA
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