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In our Brighton/Boston labs, RNA biology meets today's cutting-edge genomics, computational biology, and deep-sequencing technologies to create a new class of medicines that address the underlying causes of disease.
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Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies.
$138,500 - $153,100 a yearFull-timeExpandUpdated Today - UpvoteDownvoteShare Job
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Senior Scientist – RNA Chemistry SUMMARY:Intellia Therapeutics is seeking an experienced Senior Scientist to join the RNA Chemistry Team, which is responsible for the production of synthetic oligonucleotides.
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Demonstrated experience with routine molecular biology techniques (DNA/RNA/protein isolation, cDNA synthesis, RT-PCR, qPCR, digital PCR, western blot, and immunofluorescence) Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas.
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Perform molecular biology procedures (i.e. DNA/RNA/protein isolation and characterization, RT-PCR, enzyme assays, and multi-well plate assays) and flow cytometry-based micronucleus assays. Perform molecular biology procedures (i.e. DNA/RNA/protein isolation and characterization, RT-PCR, enzyme assays, and multi-well plate assays) and flow cytometry-based micronucleus assays.
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Skills: Small animal surgery, mouse colony management, genotyping, DNA and RNA extraction, PCR, cloning, tissue cryosection, immunohistochemistry, and lab organization management. Skills: Small animal surgery, mouse colony management, genotyping, DNA and RNA extraction, PCR, cloning, tissue cryosection, and immunohistochemistry.
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Experience leveraging high-throughput molecular or synthetic biology techniques to support protein and RNA engineering. Experience leveraging high-throughput molecular or synthetic biology techniques to support protein and RNA engineering.
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Familiarity with signal transduction, cell signaling, RNA biology, genome engineering, synthetic biology, functional genomics and screening, or related disciplines. Bachelor’s degree in Cell Biology, Genetics, Synthetic Biology, Bioengineering, Genomics, Molecular Biology, Bioinformatics, or related field.
$58,950 - $82,550 a yearFull-timeExpandUpdated Today - UpvoteDownvoteShare Job
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Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:PhD with degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering or a related scientific field with additional 8 years of independent research/ leading a scientific team in a competitive environment in RNA or closely related field demonstrated by a strong publication record.
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Designing, performing, and/or overseeing the execution of stability studies of critical materials, intermediates, drug substance and drug product related to the company’s AAV gene therapy and RNA PMO product pipelines.
$180,000 - $225,000 a yearFull-timeExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Active member of a cross-functional, high performance operational team at GreenLight's state-of- the-art & science Pilot Plant to establish a proven platform for the commercial production of RNA via a Cell Free Reaction (CFR) for agricultural applications.
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Routine tests may include virus RNA extraction, PCR, DNA sequencing, real-time PCR, plasma and PBMC isolation from whole blood, PBMC subpopulation isolation, and drug susceptibility assays with HIV-1 and HIV-2.
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Assisting with molecular biology techniques such as cloning and plasmid purification, as well as isolation and analysis of RNA, DNA, and protein from mouse tissue and cellular samples. Procedures include but are not limited to: isolation and analysis of DNA, RNA, and protein from cultured cells and animal tissues; mass spectrometry sample preparation and data analysis; and primary cell culture and mouse handling and experimentation.
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The MGH Krantz Family Center for Cancer Center Cartography Core is a new translational research facility that combines the latest advances protein and RNA biomarker staining with quantitative digital microscopy analytics to understand cancer biology.
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Experience with RNA biology and/or protein biochemistry is advantageous. Experience with RNA biology and/or protein biochemistry is advantageous. You will lead development of novel Next Generation Sequencing (NGS) experimental and computational methods that will be used across different diseases.
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