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Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time.
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Senior Scientist – RNA Chemistry SUMMARY: Intellia Therapeutics is seeking an experienced Senior Scientist to join the RNA Chemistry Team, which is responsible for the production of synthetic oligonucleotides.
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Within Ginkgo, the Mammalian Engineering team consists of a set of scientists and engineers with subject matter expertise across cell therapy, gene therapy, rna therapeutics, and biologics. Ginkgo has a number of public and confidential programs in RNA therapeutics, including developing next generation circular RNA and mRNA constructs with Pfizer, and triggering cell-type specific circularization with.
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The successful applicant will have a deep technical background in RNA biology and understands how to deploy various toolkits including cell engineering, genetics and functional genomics, NGS, and high-throughput screening approaches to design better RNA sequences that support long-term or tissue-specific translation.
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We are seeking a highly motivated Bioinformatics Scientist who wants the opportunity to significantly impact the growth and success of our RNA genomics programs. The successful scientist is expected to be self-motivated, detail oriented, have an understanding of RNA biology, and have the ability to work cross functionally between departments.
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Assisting with molecular biology techniques such as cloning and plasmid purification, as well as isolation and analysis of RNA, DNA, and protein from mouse tissue and cellular samples. Procedures include but are not limited to: isolation and analysis of DNA, RNA, and protein; cell culture; and mouse handling and experimentation.
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In our Brighton/Boston labs, RNA biology meets today's cutting-edge genomics, computational biology, and deep-sequencing technologies to create a new class of medicines that address the underlying causes of disease.
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PhD with degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering or a related scientific field with additional 8 years of independent research/ leading a scientific team in a competitive environment in RNA or closely related field demonstrated by a strong publication record.
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Proficient in cloning techniques (standard, Gibson, Golden Gate) and a wide range of molecular biology protocols (including DNA/RNA purification, various PCR methods, and NGS library prep). Conduct plasmid cloning and apply molecular biology techniques including DNA/RNA isolation, cDNA synthesis, and quantitative PCR methods.
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Experience with RNA or Oligonucleotide chemistry and biophysical techniques is required. Advance existing and establish new methods using mass spectrometry, HPLC and electrophoretic methods to characterize RNA molecules (oligos and/or mRNA.
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Work within an interdisciplinary team of molecular biologists, computational biologists, software engineers, and scientific leaders focused on developing diagnostic products using massively parallel sequencing of tumor genomic DNA and RNA.
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Routine tests may include virus RNA extraction, PCR, DNA sequencing, real-time PCR, plasma and PBMC isolation from whole blood, PBMC subpopulation isolation, and drug susceptibility assays with HIV-1 and HIV-2.
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Lead development of algorithms and new computational methods for identifying clinically-relevant alterations in tumor DNA and RNA derived from clinical cancer specimens. PhD in Bioinformatics, Computational Biology, Computer Science, or related field.
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Cellular analysis including flow cytometry, DNA / RNA isolation, PCR, western blot, and other molecular biology techniques. Cellular analysis including flow cytometry, DNA / RNA isolation, PCR, western blot, and other molecular biology techniques.
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As a Senior Scientist, you will work within the RNA Medicine team to develop a novel nucleic acid drug development platform. The Alloy RNA Medicines group is innovating a novel RNbased drug discovery platform, namely “AntiClastic”, spanning the fields of antisense therapeutics to immunomodulating therapeutics.
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