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Understanding of basic science relevant to clinical oncology (biochemistry, immunology, molecular biology and/or genetics). Nine years of drug development experience in biotechnology or pharmaceutical industry, or a combination of academia and industry.
$323,000 - $458,500 a yearFull-timeExpandApply NowActive JobUpdated 2 months ago - UpvoteDownvoteShare Job
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In this role you will partner with project teams across the preclinical and clinical development portfolio, integrating drug development across all functions, and translating strategy into execution to deliver medicines to patients.
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Equivalent combination of education and experience Experience/The Ideal for Successful Entry into Job: Drug development experience in biotechnology or pharmaceutical industry, or a combination of academia and industry.
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We can accomplish our mission by building deep expertise in large molecule end-to-end discovery such as Antibody discovery, protein engineering and optimization, molecular attribute characterization, target protein & expression sciences, and platform biology/in vitro pharmacology/assay development.
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Perform routine molecular biology techniques such as DNA/RNA purification from cells, tissues and biofluids, quantitate DNA/RNA and set up qPCR/qRT-PCR/dd-RT-PCR reactions with supervision. Serve as research technician for conducting basic to moderately complex molecular biology assays to support pre-clinical safety and toxicity studies.
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Experience in scientific disciplines related to drug discovery and development, including biology, chemistry, toxicology, and pharmacology. Deep expertise in one or more of the following areas: mathematical & statistical modelling, atomistic simulation, multiparameter optimisation, machine learning, computational biology, quantitative structure-activity relationships (QSAR) modelling.
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Design, execute and manage progression of novel research to support target and therapeutic concept validation of current and future approaches in the LCI. The validation package will incorporate primary in vitro biology, knockdown of targets, in vivo lung cancer models and translational research from clinical cohorts.
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We closely collaborate with other key functions required for selection and progression of clinical candidates, including Biology, Medicinal Chemistry, Drug Safety, Process Research, Vaccine Development, Analytical Research, Drug Metabolism and Pharmacokinetics.
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Provide strong scientific background in implementation of molecular biology assays, microbiological safety assays, compendial methods and have deep understanding of phase appropriate method verification, qualification, validation, sample and data analysis, GLP, GMP requirements, ICH and FDA guidance.
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PhD in Biology, Biochemistry, Immunology or related discipline with ≥5 years or BS/MS with ≥10 years of experience in a regulated pharmaceutical or biotechnology environment with a thorough understanding of the drug development process.
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As a project leader, develop and implement medicinal chemistry strategies for peptide drug discovery programs in early hits expansion and optimization, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, and other key functions to progress programs to Hit-to-Lead stage.
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Extensive experience in computational protein modeling, design, structural biology, and biophysics is required. PhD n Computational Biology (or other related field), with at least 2 years of relevant experience is required.
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Drug development experience in biotechnology or pharmaceutical industry, or a combination of academia and industry. MD (board certification or eligibility in Oncology or Hematology/Oncology desirable but not essential) required with a minimum of 8 years of post-residency experience.
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