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Extensive experience in computational protein modeling, design, structural biology, and biophysics is required. PhD n Computational Biology (or other related field), with at least 2 years of relevant experience is required.
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Design, execute and manage progression of novel research to support target and therapeutic concept validation of current and future approaches in the LCI. The validation package will incorporate primary in vitro biology, knockdown of targets, in vivo lung cancer models and translational research from clinical cohorts.
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We closely collaborate with other key functions required for selection and progression of clinical candidates, including Biology, Medicinal Chemistry, Drug Safety, Process Research, Vaccine Development, Analytical Research, Drug Metabolism and Pharmacokinetics.
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Bachelor’s/Master’s degree in engineering, biomedical engineering, chemistry, biology, or related field. Executes drug product development and commercialization studies, new product introduction and process validation at the commercial site.
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Perform routine molecular biology techniques such as DNA/RNA purification from cells, tissues and biofluids, quantitate DNA/RNA and set up qPCR/qRT-PCR/dd-RT-PCR reactions with supervision. Serve as research technician for conducting basic to moderately complex molecular biology assays to support pre-clinical safety and toxicity studies.
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We can accomplish our mission by building deep expertise in large molecule end-to-end discovery such as Antibody discovery, protein engineering and optimization, molecular attribute characterization, target protein & expression sciences, and platform biology/in vitro pharmacology/assay development.
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We are seeking for highly motivated Associate Scientist to complement our Discovery Biology team at the Spring House Lab Site. The successful candidate will join a dynamic, multi-disciplinary team of scientists in exploratory immuno-oncology, playing a key role in the evaluation and understanding of new drug concepts in vitro and in vivo.
$60,000 - $70,000 a yearFull-timeExpandApply NowActive JobUpdated 27 days ago - UpvoteDownvoteShare Job
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Provide strong scientific background in implementation of molecular biology assays, microbiological safety assays, compendial methods and have deep understanding of phase appropriate method verification, qualification, validation, sample and data analysis, GLP, GMP requirements, ICH and FDA guidance.
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As a project leader, develop and implement medicinal chemistry strategies for peptide drug discovery programs in early hits expansion and optimization, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, and other key functions to progress programs to Hit-to-Lead stage.
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In this role you will partner with project teams across the preclinical and clinical development portfolio, integrating drug development across all functions, and translating strategy into execution to deliver medicines to patients.
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