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Strong subject matter expertise in immune-oncology, cell therapy drug discovery and development including CMC considerations, CAR design, engineering and armoring strategies, innate immune cells such as NK and gamma delta for the purposes of leading drug development projects from start to the clinic.
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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.
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We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis.
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Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Communication, Curiosity, Data, Data Analysis, Design of Experiments (DOE), Detail-Oriented, Drug Development, Drug Discovery Process, Ethics, Gene Therapy, Group Problem Solving, Immunology, Inventory Management, Laboratory, Large Group Presentations, Leading Project Teams, Life Science, Machine Learning (Ml), Medical Research {+ 9 more.
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This is a unique opportunity for a PhD-level biologist to be involved in high-impact drug discovery projects in the newly developed Center for Therapeutic Discovery at Dana-Farber Cancer Institute.
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Responsibilities Support the development of the Drug Substance strategy and oversee manufacturing of preclinical and clinical material. Senior Director, Drug Substance Position Summary Reporting to the VP, Head of CMC Development, the Senior Director, Drug Substance will be responsible for leading the drug substance team in development and manufacturing as part of PepGen ́s CMC team.
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As a Scientist II/Sr. Scientist I at NextRNA Therapeutics, you will join an interdisciplinary team of highly creative and talented individuals whose vision is to improve patients’ lives by expanding the space of small molecules targeting RNA. You will have an opportunity to work with a diverse team of biologists, biochemists, chemists, and computational biologists to support drug discovery programs for the next wave of RNA therapeutics.
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The Hematology group in the Internal Medicine Research Unit (IMRU) is seeking a highly motivated BA/BS scientist with in vivo pharmacology experience to support preclinical drug discovery efforts for Hematology programs.
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By integrating our propriety screening technology using the body’s natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently identify novel, biologically relevant allosteric sites for protein or RNA targets, and rapidly advance structural insights into small molecule therapeutics design.
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Possessing in-depth knowledge of antibody-based discovery, optimization/ engineering using in vivo based discovery methods that include transgenic animals/ llamas and single B cell cloning methodologies and NGS to manipulate and mine antibody populations appropriately for therapeutic antibody workflows.
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The Research Associate I, Downstream CMC (Contract) position will support the Company’s intracellular biologics discovery programs. They will work closely with downstream and upstream teams to progress discovery and development programs.
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Experience advising on statutes, regulations, and guidance documents applicable to market access activities, including Medicaid, 340B program, Veterans Administration, federal and state anti-kickback statutes, state drug pricing transparency laws, OIG guidance documents and advisory opinions, the False Claims Act, and the PhRMA Code.
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For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development.
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The Associate Director, Translation Imaging Lead is the contact point for incorporating imaging biomarkers for decision-making purposes from D2 through to D8 and will achieve the above by relying on collaboration throughout the organization, in particular in Drug Discovery and Development.
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Link to register: Instructions from the Drug & Alcohol Clearinghouse, Federal Motor Carrier Safety Administration (FMCSA): Keywords: CDL A, CDL B, driver, commercial driver's license, building products, job site, building materials, distributor, distribution, touch freight, load, unload, commercial vehicle and delivery.
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drug discovery jobs Title: doctoral in Saugus, MA
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