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Knowledge of how to implement QC requirements with a variety of downstream in-vitro and in-vivo uses. Understanding the importance of how to develop production workflows and appropriate QC for in-vivo grade products is essential to the role as downstream uses include immunogenicity assays, in-vivo PK, efficacy and toxicology studies.
Full-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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The Senior Engineer Downstream contributes to the Viral Vector Process Development group through lab leadership around the design and execution of experiments to optimize AAV (Adeno-Associated Virus) manufacturing processes.
$163,000 a yearFull-timeExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Drive discussions with downstream stable CHO production groups for manufacturability. Fluid cross functional communication is critical to program success as our production team feeds into several downstream groups to help evaluate lead assets.
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Providing analytical support to Upstream and Downstream process development team activities by ensuring consistent and timely execution of standardized platform product characterization assays, including data review, storage and trending.
Full-timeExpandApply NowActive JobUpdated 17 days ago - UpvoteDownvoteShare Job
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15 plus years' experience in pharma/biotech industry with significant management experience in upstream/downstream process development and manufacturing of protein therapeutics. We are seeking a senior CMC leader with experience to advance our TCR bispecific therapies from lead candidate to clinical development, including internal upstream and downstream development of robust manufacturing processes as well as tech transfer and oversight of cGMP manufacturing at external contract development and manufacturing organizations (CDMOs.
Full-timeExpandApply NowActive JobUpdated 2 months ago - UpvoteDownvoteShare Job
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The candidate will have opportunities to work in cell culture development and purification development to become a well-rounded process development scientist with experience in upstream and downstream.
Full-timeExpandApply NowActive JobUpdated 21 days ago - UpvoteDownvoteShare Job
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Design and perform bioanalytical assays downstream of in vivo pharmacology work. Design and perform bioanalytical assays downstream of in vivo pharmacology work. Mastery in collecting material (blood, tissue, etc) for ex vivo analysis and processing with ex vivo analytical assays such as ELISA, FACS, MSD, qPCR, etc.
Full-timeExpandApply NowActive JobUpdated 16 days ago - UpvoteDownvoteShare Job
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Perform small-scale bioprocess experiments that encompass both upstream (cell culture) and downstream (purification) operations. Perform small-scale bioprocess experiments that encompass both upstream (cell culture) and downstream (purification) operations.
Full-timeExpandApply NowActive JobUpdated 17 days ago - UpvoteDownvoteShare Job
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Manage cell line development, clone selection/stability, upstream/downstream development and manufacturing operations at the CDMOs∯*∯ Significant experience developing upstream and downstream processes in support of biologics manufacturing.
$225,000 a yearFull-timeExpandApply NowActive JobUpdated 14 days ago - UpvoteDownvoteShare Job
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Good understanding of upstream and downstream processes of viral vectors, cell therapy, or recombinant biologics. Experience in process development/analytical development/MSAT or GMP pharmaceutical manufacturing.
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Develop and execute robust, scalable downstream processes for Dragonfly's novel multi-specific antibody and cytokine platforms ranging from chromatography to tangential flow and viral filtration.
Full-timeExpandApply NowActive JobUpdated 19 days ago - UpvoteDownvoteShare Job
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Experience with HPLC for downstream purification and bioreactor setup experience. Operate multiple types of instrumentation (HPLC, LCMS, FT-IR, RAMAN, Gel electrophoresis, wave rockers, cell counters, flow cytometry) with protocols under development.
Full-timeExpandApply NowActive JobUpdated 30 days ago - UpvoteDownvoteShare Job
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The Downstream Process Development Scientist will be responsible for developing and optimizing purification processes for Adeno-associated viruses (AAV), Lentiviral vectors (LVV) and Retroviral Vectors (RVV) at Genezen Lexington, MA facility.
Full-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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Inform media tagging & taxonomy governance efforts to standardize tags, categories, values, and deployment with an aim to enhance data organization and downstream campaign analytics. Data management & analysis platforms (e.g., Databricks, Snowflake, etc.
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May support various experiment preparation and execution as directed to include, but not limited to; execution of cell culture, harvest and downstream purification process studies using 500 L scale pilot equipment including bioreactors, chromatography skids and filtration systems.
Full-timeExpandApply NowActive JobUpdated 3 months ago
downstream job in Lexington, MA
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