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Perform small-scale bioprocess experiments that encompass both upstream (cell culture) and downstream (purification) operations. In this vital role you will contribute towards Amgen’s Drug Substance Process Development for late stage clinical and commercial biologics programs, including the development, characterization, and scale-up of upstream and downstream manufacturing processes supporting Ph II/III clinical trials to marketing application.
$75,623 - $92,226 a yearFull-timeExpandApply NowActive JobUpdated Yesterday - UpvoteDownvoteShare Job
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Own manufacturing technical readiness as a critical member of our cross-functional NPI teams, with specific emphasis on manufacturing return of experience, producibility, cost effectiveness, industrialization; negotiate conflicting requirements, identify lessons-learned and DFM/DFA/DFSS opportunities and share/escalate to upstream design engineers and downstream sustaining engineers.
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May support various experiment preparation and execution as directed to include, but not limited to; execution of cell culture, harvest and downstream purification process studies using 500 L scale pilot equipment including bioreactors, chromatography skids and filtration systems.
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This includes, but is not limited to, sample preparation from various tissues, instrument maintenance, method optimization, sample management and downstream analysis. The primary responsibility of this lab-based position is to support the bioanalytical throughput and execution of in vitro and ex vivo pharmacokinetic and pharmacology oligonucleotide studies, utilizing quantitative LC-MS/MS assays and/or ligand binding assays.
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10+ years of experience in biologics process development with a strong understanding of antibody processing, including upstream and downstream processes. Develop phase-appropriate drug substance processes for antibodies and proteins, including cell banking, upstream cell culture, and downstream purification.
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This position is a hands-on role, and the successful candidate will have deep knowledge and experience in the synthesis, purification, and downstream processing of long guide RNA to advance our cutting-edge gene editing drug discovery programs.
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Other downstream experiences, for instance enzyme reactions, mixing, depth filtration, tangential flow filtration, is preferred. Other downstream experiences, for instance enzyme reactions, mixing, depth filtration, tangential flow filtration, is preferred.
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Additional experience in downstream purification of biologics including chromatography separations and filtration operations (depth, dead-end, and ultrafiltration/diafiltration) is a plus. The Director will be primarily responsible for scientific leadership and technical oversight of upstream and downstream process design, development, and scalability of unit operations necessary for supporting the Target product profile of the vaccine candidates in development.
$200,000 - $240,000 a yearFull-timeExpandApply NowActive JobUpdated Yesterday - UpvoteDownvoteShare Job
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Prior experience with mRNA upstream and downstream process development. At least 2 years of experience working in an industry lab with a proven record of developing and executing novel mRNA upstream and downstream process.
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Manage and lead all external and internal aspects of process development, including upstream and downstream cell processing, viral vector production, and analytical development for Volnay’s cell therapy pipeline.
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Build and maintain our team's backend data structures in GBQ and Looker, ensuring they are set up to drive impactful downstream reporting for both Wayfair stakeholders and suppliers. Global Wellbeing: Gym/Fitness discounts (including US Peloton, Global ClassPass, and various regional gym memberships.
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Hands on support and execution for downstream purification steps such as column chromatography, harvest clarification, TFF and normal flow filtration. Fundamental understanding of protein chemistry and bioprocess engineering practices.
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Since its founding in 2016, Galehead has deployed its proprietary LandCommand® technology and specialized upstream platform to develop more than 15 GW of solar, storage, and wind projects under active development by Galehead and its Downstream Partners including Tyr Energy Development, EDF, Clearway, Rev Renewables, Steelhead, Engie, and Longroad.
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Drive standardization and implement process improvements, efficiencies and automation across the AP function with upstream and downstream processes. Work with Accounts Payable Manager to deliver Internal / External Auditors for Sox compliance requests, substantive testing and quarterly / annual audit preparation.
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The successful candidate will have a strong background and proven track record in all activities encompassing upstream and downstream processes for the manufacturing of biologics, in support of IND enabling submissions.
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downstream job in Cambridge, MA
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