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We are seeking a highly skilled and experienced Senior/Principal Scientist with a proven track record in oncology drug discovery, in vitro and in vivo pharmacological characterization, and development.
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The successful candidate will interact with a dynamic team of scientists to conduct oncology and pharmacological studies in vitro, ex vivo, and in vivo efficacy models.
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Design and perform in vitro and in vivo experiments for target ID, validation and MoA in the area of obesity and diabetes. The Scientist will provide technical leadership in complex in vitro and in vivo workflows, identification and validation of new drug targets, advancing novel therapies, and developing technologies to accelerate scientific research.
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Perform in vitro assays such as ELISA, ELISpot, Luminex, flow cytometry, and qPCR. Coordinate in vivo pharmacology research in a matrixed environment, as well as external academic collaborations and an extensive network of CROs.
Full-timeExpandApply NowActive JobUpdated 13 days ago - UpvoteDownvoteShare Job
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We are currently searching for a passionate and innovative Scientist I to Sr. Scientist who excels at in vivo and in vitro experimentation in the metabolic disease space.
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The ideal candidate will have neuroscience research experience employing a variety of in vitro/in vivo electrophysiology techniques including traditional whole-cell patch-clamp, extracellular field potential recordings, and qEEG. Additional computational or programming experience is also required.
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The successful candidate will support a variety of in vivo, ex vivo, and in vitro experiments to reveal underlying mechanistic disease biology that aid in the development of disease-modifying therapies and new drug targets.
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In-depth knowledge of (patho-)physiology of cardiovascular, renal and pulmonary mechanisms, including direct experience complex in vitro cell-based platforms recapitulating human disease phenotype and in vivo models of disease progression.
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You are ready to partner with drug discovery scientists as we evaluate gene targeting modalities and carry out analytical assays for functional validation both in vitro and in vivo.
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Lead single-cell RT-PCR, PCR, molecular cloning, and BCR sequence analysis to best harvest variable antibody regions for expression, NGS and/or repertoire cloning into in vitro display platforms, with associated analysis and management of data.
$234,300 a yearFull-timeExpandApply NowActive JobUpdated 16 days ago - UpvoteDownvoteShare Job
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Your daily responsibilities include the collection of in vitro and in vivo samples, and library preparation for genomic assays, including single cell genomics, CUT&TAG, CUT&RUN, WGS, and Amplicon-sequencing.
$175,000 a yearFull-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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Possessing in-depth knowledge of antibody-based discovery, optimization/ engineering using in vivo based discovery methods that include transgenic animals/ llamas and single B cell cloning methodologies and NGS to manipulate and mine antibody populations appropriately for therapeutic antibody workflows.
$234,300 a yearFull-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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Experience with in vivo methodologies is a plus (e.g., mouse handling, subcutaneous injection, intravenous injection, necropsy, sample analysis, histology) Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; RNA extraction and RT-qPCR.
$62 an hourExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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Design and conduct in vitro and in vivo studies to evaluate therapeutic efficacy in cancer models. Hands-on experience working with in vivo models of cancers, including blood/tissue collection and processing for ex vivo analysis.
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In vivo drug candidate testing (e.g., mouse dosing; sample analysis) Experience with RNAi and in vitro screening is preferred. Experience in cellular and molecular biology is essential (e.g., mammalian cell culture, cell-based assays, quantitative real-time PCR.
Full-timeExpandApply NowActive JobUpdated 7 days ago
vitro in vivo jobs in Cambridge, MA
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