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The ideal candidate brings expertise in mammalian cell culture, molecular biology, mammalian cell protein production, in vitro assay development and execution, and experience interfacing with automated systems.
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With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. The Clinical Data Analyst partners cross functionally to identify risk to data integrity throughout the data flow to drive quality collection for non-EDC data sources (fluid & tissue labs, digital, imaging, wearables) in Dyne's clinical studies.
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Experience in complex molecular data integration, such as transcriptomics, proteomics, and metabolomics, and in deriving insights from such analyses will be advantageous. Advantageous to have experience in complex molecular data integration, such as transcriptomics, proteomics, and metabolomics.
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Job Title: Postdoctoral Fellow Location: Cambridge, MA Duration: 12 months on Contract Description: Highlights: Strong Molecular Biology Description The Biological Process Development recently has Cell Line Development (CLD) group is responsible for producing cell lines that express clinical grade therapeutic proteins and viral vectors for Cell and Gene Therapies.
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In the dGTEx project, the individual will play an essential role in the team’s efforts to establish a comprehensive molecular resource database spanning a diverse range of tissues across developmental stages in humans and two NHP species, rhesus macaques and marmosets (the developmental Genotype Tissue Expression (dGTEx) projects.
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Familiarity with molecular biology techniques, including PCR, restriction enzyme digestion, DNA purification, SDS-PAGE, western blot and microbial transformation (bacteria, yeast). The successful candidate will employ molecular biology and microbiology techniques to support all aspects of high-throughput molecular cloning including, DNA preparation, host transformation, host growth, protein expression, sample labeling, aliquoting, record keeping in our database and electronic notebook and other related tasks.
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Post-Doctoral Position in Multi-Scale Tissue Biomechanics Lab, Boston University. A postdoctoral research position is available in Dr. Katherine Yanhang Zhang’s Multi-Scale Tissue Biomechanics Lab in the Mechanical Engineering Department at Boston University.
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Demonstrate basic knowledge of the GXP cellular therapy product manufacturing, and program development and evaluation, as well as needs assessment and marketing of the programWorking knowledge of flow cytometry, molecular biology, and genetic engineering is a plus.
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Experience working with primary human tissue samples, and in vivo models of autoimmunity and inflammation is preferred. Strong hands-on skills in molecular biology are a plus. Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection, functional immune cell assays (proliferation, cytotoxicity, chemotaxis) and assay development is essential.
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Basic wet lab skills, including but not limited to, molecular biology and biochemistry techniques such as DNA and RNA extraction, lysate preparation, qPCR, protein quantification, Western blot/WES/JESS, and ELISA is preferred.
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PREFERRED BUT NOT REQUIRED- Are you seeking a generalist [proficient in testing in all Chemistry, Hematology, Urinalysis, Coagulation] or are you seeking a Micro Lab worker with Molecular background.
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Projects involve discovery of chemical dark matter in the microbiome and functional characterization of bioactive metabolites to identify host cellular responses and molecular targets that mediate interactions between the microbiome and the host immune system.
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Microscopy, tissue imaging (IHC, fluorescence microscopy), flow cytometryExcellent written and oral communication skills including good presentation skillsStrong business acumen; including knowledge of the multidisciplinary functions involved in a company’s drug development process, e.g., clinical operations, research, biostatistics, clinical pharmacology, regulatory, commercial operations, etc.
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PhD in cell or molecular biology or a related field, ideally with 2 or more years post-degree experience preferably in drug discovery and in an industry setting. Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening (e.g., transfection); cell-based assays ; PCR.
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Role Responsibilities: Conduct routine end-to-end molecular biology and biochemistry techniques including but not limited to: Cell transformations, day cultures, bacterial cultures, plasmid purification and digestions.
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molecular tissue jobs Title: post doctoral fellow Company: Emory University in Brookline, MA
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