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The Postdoctoral Fellow will embark on a research project aiming to define cellular and molecular mechanisms of chronic injury resolution. What You Will AchieveThe Myeloid and Tissue Remodeling group, as part of Inflammation and Immunology Research Unit, at Cambridge, MA is seeking a highly driven and innovative Ph. D.-level scientist to join our discovery group as postdoctoral research fellow in driving therapeutic innovation through exploration of fibrotic disease pathophysiology.
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Familiarity with molecular biology techniques, including PCR, restriction enzyme digestion, DNA purification, SDS-PAGE, western blot and microbial transformation (bacteria, yeast). The successful candidate will employ molecular biology and microbiology techniques to support all aspects of high-throughput molecular cloning including, DNA preparation, host transformation, host growth, protein expression, sample labeling, aliquoting, record keeping in our database and electronic notebook and other related tasks.
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Analyze, visualize and summarize NGS and other molecular data from oncology clinical trials and proprietary and public large molecular databases, including bulk tissue nucleotide acid sequencing and periphery comprehensive molecular assays including TCR sequencing, protein profiling, immune activation assays, and liquid biopsies.
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Analysis of blood and tissue samples using a variety of techniques, including flow cytometry, ELISA, Luminex and other molecular and cell biology techniques. Animal manipulation (handling, i.p., i.v., s.c., and i.m. injections), sample collection, as well as tissue processing in compliance with IACUC protocols and animal welfare standards.
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Help with processing mouse brain and spinal cord tissue immunohistochemistry (perfusions, cryosectioning, immunohistochemistry staining, and microscope imaging). Cell characterization using molecular biology (qPCR) and protein assessment techniques (Western Blotting, immunocytochemistry), as well as imaging of fixed cell preparations.
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Experiments include in vivo assays, DNA/RNA/protein isolation and quantification including molecular biology techniques such as Gel Electrophoresis, qPCR, Western blot, and ELISA, tissue culture, microscopy, and various immunological assays.
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Job Title: Postdoctoral Fellow Location: Cambridge, MA Duration: 12 months on Contract Description: Highlights: Strong Molecular Biology Description The Biological Process Development recently has Cell Line Development (CLD) group is responsible for producing cell lines that express clinical grade therapeutic proteins and viral vectors for Cell and Gene Therapies.
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Mechanism of Action Studies: Investigate the molecular mechanisms underlying the activity of Cell Therapy candidates using in vitro pharmacology approaches. Proven track record of leading successful in vitro pharmacology efforts in the field of Cell Therapy, including assay development and validation, candidate screening, and mechanism of action studies.
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A Doctoral Degree in biochemistry, molecular biology or related field with a minimum of eight years of experience in the biotechnology/pharmaceutical industry and/or an academic setting (industry experience is preferred.
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Specific roles and responsibilities include:· Leverage existing datasets with blood, CSF, neuroimaging biomarkers, and post-mortem human brain tissue available for clinical research. PRINCIPAL DUTIES AND RESPONSIBILITIES:The MGH-McCance Center for Brain Health-BNL has an open Post-Doctoral Research Fellow position to explore existing and establish new datasets that identify modifiable risk factors for mitigation through interventional studies in people at risk for dementia.
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In addition, this role focuses on performing the following CT Scan duties: Utilizes CT Scan Technology to provide images of internal organs, bones, and soft tissue. Comprised of Tufts Medical Center, Lowell General Hospital, MelroseWakefield Hospital, Lawrence Memorial Hospital of Medford, Care at Home - an expansive home care network, and large integrated physician network.
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Perform molecular analysis of nucleic acid and protein levels in animal tissue to support preclinical development efforts. Extensive experience with standard molecular biology techniques (DNA/RNA extraction, PCR, qPCR, etc.
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The successful candidate will work with his/her supervisor to design, plan and conduct molecular biology and cell culture experiments to evaluate strategies to improve AAV production platforms through expression vector modification and/or host cell line engineering.
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With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. The Clinical Data Analyst partners cross functionally to identify risk to data integrity throughout the data flow to drive quality collection for non-EDC data sources (fluid & tissue labs, digital, imaging, wearables) in Dyne's clinical studies.
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Inimum of 7+ years of hands-on experience in plant tissue culture, with a deep understanding of plant cell biology as it relates to cotton. The ideal candidate will have deep knowledge and experience in cotton cell biology, tissue culture techniques, and microscopic examination.
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molecular tissue jobs Title: post doctoral fellow Company: Emory University in Boston, MA
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