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We are looking for a motivated Upstream Process Development Principal Scientist to join the mRNA Drug Substance (DS) team and work on delivering new mRNA vaccine candidates from development to clinical manufacturing stages, a role located in Cambridge, MA USA, and reporting to the RNA DS Platform Development Leader (Belgium based.
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Experience in synthetic peptide and/or peptide antibody conjugates including theoretical knowledge, research, and hands-on experience to support process development/scale up activities and formulation development.
$42 an hourFull-timeExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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The laboratory of Dr. Levi N. Kanu of Schepens Eye Research Institute at Massachusetts Eye and Ear is seeking a full-time Postdoctoral Associate for the development and optimization of ocular drug delivery systems for corneal wound healing.
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Lead and manage multiple drug discovery projects, oversee the entire drug development process from target identification to preclinical development; Deep understanding of the drug discovery process, including target identification, hit-to-lead optimization, and preclinical development.
$322,300 a yearFull-timeExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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Director/Sr. Director - Process DevelopmentGreater Boston Area Competitive Compensation + excellent bonus/benefitsDuties and Responsibilities:Lead all process development activities (cell culture/banking/development, fermentation, protein purification, tech transfers)Oversee internal(in-house) and external vendors (domestic & international CDMOs)Work cross-functionally with CMC & Manufacturing leaders such as Analytical, Drug Product, QA/QC, Manufacturing, Supply Chain, etc.
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Experience with Tech transfer to CDMO for non-GMP and GMP manufacturing, including cell line development, process development, analytical method development and manufacturing scale up.
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Chemistry, Clinical Pharmacology, Clinical Research, Clinical Study Reports, Clinical Trials, Data Entry, Drug Discovery, Due Diligence, Electronic Components, Gene Therapy, Lifesciences, Medical Research, Microsoft Office, Modeling And Simulation, Patient Care, Physics, Translational Medicine, Waterfall Project Management.
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Frontage Laboratories Inc. is an award-winning, publicly listed, science driven, full-service global CRO, founded 23 years back and is HQ in Exton, PA. We operate over 25 state-of-the-art facilities across the US, Canada, China and Europe providing comprehensive portfolio of services including Drug Discovery, Drug Development, Bioanalytical Services, Pharmaceutical Product Development, and Laboratory services.
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The respective team is focused on various critical activities with Technical Operations (CMC), including sgRNA and lipid manufacturing/process development. This is a hands-on role in Oligonucleotide (sgRNA) process development for CRISPR/Cas 9 with the opportunity to support Intellia’s development pipeline for generating curative genome editing therapies.
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Direct the planning and implementation of process development, scale-up, technology transfer, and validation efforts in drug substance manufacturing, ensuring strategic alignment and operational excellence.
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Job Summary The Principal Scientist of Analytical Development and QC at Foghorn Therapeutics will drive the analytical development and QC functions, ensuring the successful advancement of small molecule candidates from preclinical through NDA for both drug substances and drug products.
$198,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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We emphasize mechanistic biology, including (1) canonical and non-canonical roles of BCL-2 family apoptotic proteins, (2) the p53 and RAS pathways, (3) high priority metabolic, bacterial and viral targets, and (4) novel helix-in-groove interactions relevant to protein structure, function, and drug development.
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This position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of mechanistic research, drug discovery, and preclinical drug development.
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Background encompasses manufacturing process development of parenteral drug product, including oligos, protein, peptide, viral or cell therapeutics. Extensive experience in parenteral drug product process development.
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Oversee in vivo and in vitro studies, including development and optimization of disease models, study design, data collection, and interpretation. Develop and validate immunological assays (, flow cytometry, ELISA, CyTOF, cytokine profiling) to evaluate drug candidates' efficacy and mechanism of action.
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process drug development jobs Title: director operations in Boston, MA
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