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Biotechnology company is hiring a Scientist to contribute towards recombinant protein expression and purification efforts to support drug discovery activities. Operate high performance liquid chromatography systems (HPLC) for protein purification and analysis.
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Protein expression and purification efforts to support drug discovery activities. Strong protein purification expertise in affinity and size exclusion chromatography. Protein purification using a variety of chromatographic techniques (affinity, size.
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In this role, you will play a key part in the discovery and advancement of small molecule drug candidates, by enabling protein expression and purification activities for biochemical, biophysical, and structural enablement.
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The selected individual will contribute towards recombinant protein expression and purification efforts to support drug discovery activities. Operating and maintaining High performance liquid chromatography systems (HPLC) for protein purification and analysis.
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Must have experience in cell-based assay development and execution across different cellular assay formats to enable small molecule drug discovery/characterization, ideally with some emphasis on transcriptional readouts (qPCR, luciferase-based reporters, CUT&RUN, CUT&Tag, ChIP-seq, HTFR, BRET, ALPHA screen, ELISA, Protein Simple, western, etc.
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In addition to assay development and fit for purpose mechanistic studies, this role focuses on the application of novel methodologies to the in vitro and ex vivo studies conducted by Safety Assessment as well as support for routine toxicology assay screening for drug discovery programs.
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Working closely with discovery scientists (biologists, (protein)chemist, biochemist, pharmacologist, toxicologists) to codify their knowledge and discover new insights using advanced PKPD modeling techniques.
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Immediate opening available for a Research Associate position to work in the drug discovery team to support ongoing efforts to generate preclinical data for small molecules targeting RNA. Key responsibilities will be to run routine qPCR, cell proliferation, RNA sequencing, ELISA, and other biochemical and cellular assays in high throughput format using liquid handler to support ongoing drug discovery projects.
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Parvus’ leadership team is experienced in successful drug discovery, development, manufacturing, regulatory approval, and commercialization. Primary Responsibilities: Primary contributor with protein characterizing mass spectrometry experiments, including maintaining the instrument, developing and performing experiments with an emphasis on intact mass, glycan analysis and peptide mapping studies.
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We are seeking an experienced Computational Chemist to be a founding member of our Drug Discovery Team. In this position you will work in close conjunction with our Medicinal Chemistry Team in the design and optimization of a completely novel class of therapeutics.
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EProtein promises to be a breakthrough protein expression, characterization and purification technology that brings rapid protein access to the life science benchtop and accelerates drug discovery process.
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The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
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B.S. or M.S. with 2+ years of relevant research experience, preferably in drug discovery in pharmaceutical or biotechnology industry. · Attention to detail and enthusiasm for integrating basic science learning with drug discovery efforts.
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Reporting to the CSO, you will lead a team of drug discovery professionals in areas including: medicinal chemistry; DNencoded chemical library design, synthesis and screening; complex biologics (including antibody-drug conjugates, ADCs); oligonucleotides; analytical sciences; PKDM; protein sciences and structural biology.
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Septerna is a biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company, and a mission to develop life-changing medicines for patients.
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drug discovery protein jobs in South San Francisco, CA
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