Amgen Inc

In this vital role you will characterize the absorption, distribution, metabolism, excretion and pharmacokinetic (ADME) properties of therapeutic drug candidates to achieve their full pharmacological potential.. Planning and execution of mechanistic PKPD analyses to integrate knowledge of drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics, and to optimize selection doses and preclinical study designs.. Working closely with discovery scientists (biologists, (protein)chemist, biochemist, pharmacologist, toxicologists) to codify their knowledge and discover new insights using advanced PKPD modeling techniques.. Candidate should have solid technical expertise in quantitative pharmacology and strong hands-on modeling and simulation experience with Pheonix WinNonlin, R, SimBiology, SimCYP, GastroPlus and/or other modeling and simulation software and data visualization tools.. PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training

quantitative

HOW MIGHT YOU DEFY IMAGINATION? If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Director, Quantitative Pharmacology Live What You Will Do Let’s do this. Let’s change the world. In this vital role you will characterize the absorption, distribution, metabolism, excretion and pharmacokinetic (ADME) properties of therapeutic drug candidates to achieve their full pharmacological potential. In this role, your core responsibilities include leading a team of pre-clinical PKPD, PBPK and QSP modelers responsible for: <ul><li>Planning and execution of mechanistic PKPD analyses to integrate knowledge of drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics, and to optimize selection doses and preclinical study designs.</li><li>Working closely with discovery scientists (biologists, (protein)chemist, biochemist, pharmacologist, toxicologists) to codify their knowledge and discover new insights using advanced PKPD modeling techniques.</li><li>Contributing to the analysis of pre-clinical PKPD data for IND and NDA/BLA filings, and documentation in appropriate reports.</li><li>Work closely with business development group to evaluate external opportunities</li><li>Build close relationships with partner functions and therapeutic areas </li></ul>Win What We Expect Of You We are all different, yet we all use our unique contributions to serve patients. The professional we seek will possess these qualifications. Basic Qualifications: <ul><li>The ideal candidate will have a strong background in integrating preclinical data sets to aid in the development of translational PK/PD models.</li><li>Candidate should have solid technical expertise in quantitative pharmacology and strong hands-on modeling and simulation experience with Pheonix WinNonlin, R, SimBiology, SimCYP, GastroPlus and/or other modeling and simulation software and data visualization tools.</li><li>Experience in managing and mentoring junior modelers and scientists</li><li>Ability to drive the progression of discovery and development project teams</li><li>Lead development of scientific strategy across PKDM initiatives with a focus on development of integrated PK/PD, QSP and PBPK models to aid in translation.</li><li>Develop and mentor PKDM staff. Establish modeling workflows for PKDM scientists. </li></ul>Preferred Qualifications: <ul><li>PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training</li><li>Expertise in PK/PD and translational modeling</li><li>Experience in supporting preclinical/clinical PK, PK/PD, and modeling & simulation components of regulatory documentations.</li><li>Excellent interpersonal, technical, and communication skills to lead cross-functional teams</li><li>Past experience as a laboratory scientist and in a biotech environment</li><li>Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills</li><li>Record of scientific contributions through peer-reviewed articles and external presentations </li></ul>Thrive What You Can Expect Of Us As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: <ul><li>Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.</li><li>A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan</li><li>Stock-based long-term incentives</li><li>Award-winning time-off plans and bi-annual company-wide shutdowns</li><li>Flexible work models, including remote work arrangements, where possible </li></ul>Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. careers.amgen.com Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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