Novartis Group Companies

Sr Principal Scientist/ Assoc Director, Translational Modeling (M&S). We are seeking an experienced translational modeler eager to accelerate drug discovery & development by facilitating rigorous decision making with modeling & simulation, from target identification to first-in-human studies and beyond.. Ph. D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field with 6+ years of industry experience, or a master's degree with 10+ years of industry experience.. Extensive industry experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is required.. Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.

principal scientist

395160BR Sr Principal Scientist/ Assoc Director, Translational Modeling (M&S) USA About the role This role is located at our Cambridge, MA site and will not have the ability to be located remotely. #LI-Hybrid About the role: We are seeking an experienced translational modeler eager to accelerate drug discovery & development by facilitating rigorous decision making with modeling & simulation, from target identification to first-in-human studies and beyond. You will work in a multi-disciplinary environment with opportunities to engage in projects that span different therapeutic modalities. This role reports to a PK Sciences Translational Modeling team lead, in a group situated within Biomedical Research, the research engine of Novartis. Key responsibilities: * Act as the Translational M&S representative on programs in oncology, developing and executing modeling strategies, contributing to project team discussions, and guiding therapeutic design and dose selection decisions. * Build and apply QSP and physiologically based PK (PBPK) models that link drug pharmacology, tissue biodistribution, mechanism(s) of action, and biological outcomes. * Collaboratively develop integrated modeling platforms that bridge data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups. * Contribute to programs across therapeutic modalities and disease indications, as needed. Novartis has a broad portfolio of drug discovery and clinical development projects and you will have opportunities to grow and develop as you apply modeling insights to diverse projects. * Proactively seek opportunities to increase the impact and awareness of translational modeling through communications with internal and external audiences. * Contribute to group strategy and serve as an M&S subject area expert across PK Sciences and Biomedical Research initiatives. Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $166,400 - $249,600/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. https://www.linkedin.com/posts/novartis_novartis-careers-activity-7167819672107642880-Wh15/?utm_source=share&utm_medium=member_desktop #ModelingAndSimulation #PKSciences #TranslationalMedicineQuants EEO Statement We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message: Novartis: e-mail us.reasonableaccommodations@novartis.com or call +1 (877)395-2339 Sandoz: e-mail reasonable.accommodations@sandoz.com or call: +1-609-422-4098 Role Requirements Essential requirements:
* Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field with 6+ years of industry experience, or a master's degree with 10+ years of industry experience. Candidates with a Pharm.D. or background in mathematics or other quantitative fields and a deep understanding of biological concepts will be considered.
* Extensive industry experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is required.
* Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
* Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making. Demonstrated ability to independently develop and implement modeling strategy across a disease area and/or modality platform.
* Fluent in English (oral and written) Why Novartis: Our purpose is to reimagine medicine to improve and extend people's lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
You'll receive:
You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook.
https://www.novartis.com/careers/benefits-rewards
Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $166,400 - $249,600/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Division Biomedical Research Business Unit Translational Medicine Work Location Cambridge, MA Company/Legal Entity NIBRI Functional Area Research & Development Job Type Full Time Employment Type Regular Shift Work No Early Talent No #J-18808-Ljbffr

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