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Postdoctoral Scholar - Health Sciences Research Institute
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$64,480 a year
Full-time
- A postdoctoral position is available at the University of California, Merced to study the molecular mechanisms for DNA recognition, scanning and nucleosome engagement by pioneer transcription factors and their role in cell fate decisions.
- The project addresses the investigation of DNA recognition processes by pioneer transcription factors that function as master regulators of cell fate with a focus on the mechanisms of DNA protein interactions, DNA scanning, protein conformation and DNA shape changes induced by binding, as well as their
- The research will primarily involve protein biochemistry combined with advanced single-molecule biophysical methods, including ultrafast smFRET spectroscopy, force spectroscopy via optical tweezers, and correlative confocal fluorescence microscopy to investigate protein-DNA interaction dynamics.
- Experimental biophysics studies will be complemented with computer simulations and high-throughput DNbinding selection assays and genome editing studies of Candida albicans as model system to investigate the significance of the mechanisms we identify biophysically in controlling a simple in vivo model of cell fate.
- Previous training and established track record in experimental protein biophysics and/or biochemistry/protein chemistry.
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