Syracuse University

We currently seek a researcher with background in biophysics and/or biochemistry to examine the physicochemical properties that determine physiological phase separation using molecular approaches such as NMR spectroscopy, small angle scattering, and single molecule FRET.. Our lab works with many other research labs at Syracuse University in the Departments of Biology and Chemistry as well as throughout the country, including the University of Michigan and St. Jude Children's Research Hospital.. Possess skills in molecular cloning, protein expression, and protein purification.. Develop and codify quantitative methods to analyze protein interactions and contributions to modulating phase separation and condensate formation/dissolution (including modeling, scripting in Python and R, Matlab, Mathematica, etc.). Syracuse and Central New York present a wide range of seasonal recreation and attractions ranging from water skiing and snow skiing, hiking in the Adirondacks, touring the historic sites, visiting wineries along the Finger Lakes, and biking on trails along the Erie Canal.

postdoctoral researcher

Posting Details Posting Details Job # 076990 Job Title Postdoctoral Researcher - Biochemistry Location Syracuse, NY Pay Range $55,500 - $57,480 FLSA Status Exempt Hours As determined by principal investigator Job Type Full-time Rank Post Doc Campus Syracuse, NY Unionized Position Code Not Applicable Job Description The Castaeda lab uses a variety of biochemical and biophysical methods and techniques to uncover fundamental aspects of how proteins undergo liquid-liquid phase separation.We aim to determine how protein quality control mechanisms interface with membraneless organelle assembly and disassembly, particularly in how cells respond to stress. We currently seek a researcher with background in biophysics and/or biochemistry to examine the physicochemical properties that determine physiological phase separation using molecular approaches such as NMR spectroscopy, small angle scattering, and single molecule FRET. Our lab has multiple projects that focus on the role of liquid-liquid phase separation as it relates to the structure and function of ubiquitin-binding shuttle proteins.We are looking for driven and excited scientists to join our growing research group.The candidate will enter an openly collaborative environment with excellent colleagues/mentors and biophysical resources. Our lab works with many other research labs at Syracuse University in the Departments of Biology and Chemistry as well as throughout the country, including the University of Michigan and St. Jude Children's Research Hospital.The aims of the project are to examine how protein quality control components (including the proteasome, polyubiquitin chains, etc.) regulate the assembly and disassembly of biomolecular condensates, and to elucidate the underlying mechanisms of how domain-domain interactions alter and modulate phase separation. The researcher will join an interdisciplinary environment with opportunities to learn new techniques and develop new research directions and ideas.Specific research goals will be discussed and agreed with the principal investigator. Qualifications <ul><li>Have a PhD or nearing completion of a PhD in biophysics or related area (e.g. biochemistry)</li><li>Possess skills in molecular cloning, protein expression, and protein purification.</li><li>Have excellent oral and written communication skills, pays attention to detail, is eager to present ideas and results at group meetings and conferences, and is highly organized with data management.</li></ul> Job Specific Qualifications <ul><li>Excited to lead new experiments to quantify phase transitions (e.g. UV/Vis spectrophotometric assays, light scattering, microscopy).</li><li>Willing to learn or have experience with biomolecular NMR spectroscopy of folded proteins or intrinsically disordered proteins.</li><li>Skilled or interested in using and developing other biophysical methods such as light scattering, small angle scattering, single molecule FRET.</li></ul> Responsibilities <ul><li>Lead and be a team player in designing and executing biochemical and biophysical experiments, small angle scattering experiments, and other biophysical techniques to probe the structure, dynamics, and function of proteins involved in protein homeostasis and protein quality control pathways.</li><li>Clone, express and purify proteins from bacterial and other model systems</li><li>Develop and codify quantitative methods to analyze protein interactions and contributions to modulating phase separation and condensate formation/dissolution (including modeling, scripting in Python and R, Matlab, Mathematica, etc.)</li><li>Write detailed experimental protocols and keep meticulous lab notebooks</li><li>Communicate results clearly both in oral and written formats including talks, poster sessions, and journal articles.</li><li>Mentor graduate and undergraduate students, purchase supplies, maintain instrumentation, participate in literature discussions, and contribute to writing proposals.</li><li>Other duties as assigned.</li></ul> ?HEJ Physical Requirements Tools/Equipment Application Instructions In addition to completing an online application, please attach a curriculum vitae, cover letter, and a list of references. About Syracuse University Syracuse University is a private, international research university with distinctive academics, diversely unique offerings and an undeniable spirit. Located in the geographic heart of New York State, with a global footprint, and nearly 150 years of history, Syracuse University offers a quintessential college experience. The scope of Syracuse University is a testament to its strengths: a pioneering history dating back to 1870; a choice of more than 200 majors and 100 minors offered through 13 schools and colleges; nearly 15,000 undergraduates and 5,000 graduate students; more than a quarter of a million alumni in 160 countries; and a student population from all 50 U.S. states and 123 countries. For more information, please visit www.syracuse.edu. About the Syracuse area Syracuse is a medium-sized city situated in the geographic center of New York State approximately 250 miles northwest of New York City. The metro-area population totals approximately 500,000. The area offers a low cost of living and provides many social, cultural, and recreational options, including parks, museums, festivals, professional regional theater, and premier shopping venues. Syracuse and Central New York present a wide range of seasonal recreation and attractions ranging from water skiing and snow skiing, hiking in the Adirondacks, touring the historic sites, visiting wineries along the Finger Lakes, and biking on trails along the Erie Canal. EEO Statement Syracuse University is an equal-opportunity, affirmative-action institution. The University prohibits discrimination and harassment based on race, color, creed, religion, sex, gender, national origin, citizenship, ethnicity, marital status, age, disability, sexual orientation, gender identity and gender expression, veteran status, or any other status protected by applicable law to the extent prohibited by law. This nondiscrimination policy covers admissions, employment, and access to and treatment in University programs, services, and activities. Commitment to Supporting and Hiring Veterans Syracuse University has a long history of engaging veterans and the military-connected community through its educational programs, community outreach, and employment programs. After World War II, Syracuse University welcomed more than 10,000 returning veterans to our campus, and those veterans literally transformed Syracuse University into the national research institution it is today. The University's contemporary commitment to veterans builds on this historical legacy, and extends to both class-leading initiatives focused on making an SU degree accessible and affordable to the post-9/11 generation of veterans, and also programs designed to position Syracuse University as the employer of choice for military veterans, members of the Guard and Reserve, and military family members. Commitment to a Diverse and Inclusive Campus Community Syracuse University maintains an inclusive learning environment in which students, faculty, administrators, staff, curriculum, social activities, governance, and all other aspects of campus life reflect a diverse, multi-cultural, and international worldview. The University community recognizes and values the many similarities and differences among individuals and groups. At Syracuse, we are committed to preparing students to understand, live among, appreciate, and work in an inherently diverse country and world made up of people with different ethnic and racial backgrounds, military backgrounds, religious beliefs, socio-economic status, cultural traditions, abilities, sexual orientations and gender identities. To do so, we commit ourselves to promoting a community that celebrates and models the principles of diversity and inclusivity. Quick Link https://www.sujobopps.com/postings/98708 Job Posting Date 04/21/2023 Application Deadline Open Until Filled Yes Priority Consideration Job Category Faculty Message to Applicants

START NEW SEARCH