Neogene Therapeutics

Position Summary The Senior Associate, Analytical Development will be responsible for the execution of routine testing, including but not limited to flow cytometry assay, cell-based cytotoxicity assay, or PCR-based assay, to characterize or release engineered TCR-T cell drug product.. This role is based out of Santa Monica, CA and reports directly to the Senior Scientist, Analytical Development.. Essential Functions and Responsibilities Perform routine analytical testing to characterize TCR-T cell product or manufacturing process using digital PCR assay, flow cytometry, cell-based assay, or ELISA. Support lot release testing for TCR-T cell product if needed.. Hands-on experience in multi-color flow cytometers and analysis software (e.g. FACSDiva or FlowJo) is highly desired.. Experience in executing cell-based assay, flow cytometry-based assay, or digital PCR-based assay, and assist in troubleshooting aforementioned assays.

analytical development

Pushing the frontier of solid cancer therapy, Neogene Therapeutics is a global, clinical stage biotechnology company built on the premise of innovation and novel paradigm-changing science. Using tumor mutation profiles to engineer fully individualized T cell therapies, Neogene is bringing new hope to address the current limitations of treatments available today. We offer the opportunity to join a highly dynamic biotech with locations in Amsterdam, Netherlands and in Santa Monica, CA. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. Neogene values pro-active team-players who pursue their goals with dedication, endurance, and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide an exciting opportunity for your career. Position Summary The Senior Associate, Analytical Development will be responsible for the execution of routine testing, including but not limited to flow cytometry assay, cell-based cytotoxicity assay, or PCR-based assay, to characterize or release engineered TCR-T cell drug product. Additionally, this role may contribute to the daily operational tasks in Analytical Development team. This role is based out of Santa Monica, CA and reports directly to the Senior Scientist, Analytical Development. Essential Functions and Responsibilities Perform routine analytical testing to characterize TCR-T cell product or manufacturing process using digital PCR assay, flow cytometry, cell-based assay, or ELISA. Support lot release testing for TCR-T cell product if needed. Support lot release or stability testing of raw materials using plate-based assays or other immunoassays. Participate in writing and revising test methods, SOPs and/or other documents as appropriate. Participate in tracking assay results and test method performance parameters. Participate in assay qualification activities if needed. Assist in everyday operation of analytical laboratories, including but not limited to equipment management and reagent inventory. Assist in building result dataset for data visualization. Complete projects, testing and tasks as assigned and report results by de0adlines. Support cross-functional projects with process development, manufacturing, quality control, and quality assurance groups. Required Skills/Abilities Hands-on experience in performing qPCR (or d(d)PCR), flow cytometry-based assays, and/or cell-based assays is required. Hands-on experience on characterizing CAR-T, TCR-T or other immune cell-based therapy products is highly desired. Hands-on experience in multi-color flow cytometers and analysis software (e.g. FACSDiva or FlowJo) is highly desired. Proficient in molecular biology assay (e.g. qPCR or d(d)PCR) is preferred. Detail-oriented in both technical assay execution and data analysis. Working knowledge in data visualization software (e.g.Tableau or Spotfire) is a plus. Strong verbal, written and presentation skills for scientific studies and projects is desired. Enjoy a fast-paced, dynamic team and company environment and able to adjust workload based upon changing priorities. Education and Experience BS degree in Biochemistry, Cell Biology, or related discipline with 4-6 years of relevant experience, or Master’s degree in Immunology, Molecular Biology, or relevant field with 2-4 years of relevant experience. Experience working in Cell therapy area is highly desired. Experience in executing cell-based assay, flow cytometry-based assay, or digital PCR-based assay, and assist in troubleshooting aforementioned assays. Experience working in a regulated environment (e.g. GMP, GLP, or CLIA) is a plus. The anticipated salary range for candidates who will work in Santa Monica, CA is $70,000 - $82,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job type and length of experience within the industry, education, etc. Note: At this time, Neogene is not sponsoring VISAs. DE&I Statement Headline: We embrace our individual differences. "Our mission is to build a workforce reflective of our communities to be receptive to patients' broad and unique perspectives, enabling us to empathize with their needs. Together, we strive to uphold a value system that promotes: Opportunities for continuous learning to drive behavioral change and to be respectful of other points of view A collaborative culture that leverages the diverse perspectives of employees and supports courage Zero tolerance for discrimination We are committed to an emotionally and psychologically safe workplace that trusts employees to boldly explore innovative solutions. We recognize that intentionally embracing diversity at Neogene, empowers us to better relate to patients, and advance our mission to deliver cures where none exist.”

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