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In this Scientific Senior Director role you will lead a team that is responsible for driving the neuroscience portfolio by providing platforms and technologies that be utilized for target validation, biomarker identification and supporting SAR in drug discovery programs.
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In-depth knowledge and understanding of the drug discovery and drug development processes. Strong knowledge of key pharmaceutical functions throughout all stages of product development, including Marketing (e.g., Market Research, Market Access), HEOR, Medical Affairs, Preclinical, Clinical, Regulatory, CMC (e.g. supply chain, drug delivery), etc.
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For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development.
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Work collaboratively with functional partners including Clinical Development, Biostatistics, Discovery, Translational Medicine, CMC, Toxicology, DMPK, Clinical Operations and Regulatory to deliver on project and corporate objectives.
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Approaches to accelerate drug development using high dimensionality data (e.g., high content imaging, transcriptomics and proteomics data) combined with advanced analytics. value of human data in precision drug development including molecular datasets and human cell models.
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Discovery Pharmaceutical Sciences (DPS) is a multidisciplinary research group that enables drug discovery and drug product development through application of pharmaceutical science to drug delivery research from target identification through clinical candidate selection for both small and large molecules as well as vaccines.
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Coordinate with advanced analytics and machine learning teams to use knowledge graph for insights, predictions, and innovation in drug discovery and development. This team focuses on building innovated data products and solutions for the entire drug discovery and development value chain: from target ID/Validation, molecule design, product development, clinical trial design, digital end points, clinical trial operations, and using real world data to advance our portfolio.
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Reporting directly to the Analytical Development (AD) and Testing Lead, the Analytical Development (AD) and Testing Senior Analyst will support the management of the life cycle of analytical development for in-process, release and stability program testing of raw materials, plasmids, cell/bacterial banks, drug substance and drug products, in support of discovery, development, and manufacturing of iECURE’s product portfolio from the clinic through commercial launch.
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Executes drug product development and commercialization studies, new product introduction and process validation at the commercial site. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.
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A minimum of 8 years related experience in drug development, including target discovery and validation is required. Experience in advancing biologics from early discovery to clinical development is required.
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