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Associate Principal Scientist - Antibody-Drug Conjugates Portfolio Team, Solids. As a key member of our antibody-drug conjugates (ADCs) portfolio team, you will lead a team focused on bringing new ADC projects into the portfolio and advancing them through all stages of pre-clinical development.
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You will also maintain technical expertise in preclinical safety approaches applied to Immuno-Oncology therapeutics or Antibody Drug Candidates and awareness of industry trends. - Experience with the design and execution of in vivo studies to determine the effects of T Cell Engagers or Antibody Drug Conjugates on biological systems with line of sight to human safety may be considered an advantage.
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With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.
ExpandApply NowActive JobUpdated 7 days ago - UpvoteDownvoteShare Job
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As core member of multi-disciplinary drug discovery teams, you will direct investigative toxicology strategies to predict, assess and mitigate target- and modality-related safety risks in discovery programs, with a focus on Antibody-Drug Conjugates.
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Develop a computational platform for protein and antibody engineering. Integrate cutting edge AI techniques into protein and antibody design. Develop pipelines for protein docking and antibody mapping.
Full-timeExpandApply NowActive JobUpdated 6 days ago - UpvoteDownvoteShare Job
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This is your chance to join our Tumor Targeted Delivery team in Early Oncology in Gaithersburg, MD USA. As a Senior Scientist, you will lead target validation efforts for tumor-targeted therapies, such as antibody-drug-conjugates (ADCs) and targeted radio-conjugates.
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MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. A minimum of 7 years of experience in quality assurance and/or quality compliance within a biopharmaceutical or pharmaceutical manufacturing environment.
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Collaborates with partners and CDMOs for tech transfer and method validation as needed. Working knowledge of SoftMax Pro, Prism and JMP. Performs routine analytical testing including complex methods such as ELISA, Bioassays, and Cell Culture as well as basic methods such as concentration by UV absorbance, pH, conductivity, and osmolality, for in-process, product release, and stability samples on a daily basis in accordance with all protocols and procedures.
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Generate, interpret, and communicate in silico data, and communicates data with the department lead as well as with project teamsContribute to the overall computational antibody strategy for multiple new drug R&D projects and play an active part in its implementationCollaborate with experimental researchers to validate and optimize designed antibodies through in vitro and in vivo assays.
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Perform transient transfection and antibody/protein purification. Extensive and current hands-on experience with phage and yeast-display technology for antibody discovery. The successful applicant is expected to have good understanding of a range of procedures related to recombinant antibody identification using phage and yeast-display.
Full-timeExpandApply NowActive JobUpdated 14 days ago - UpvoteDownvoteShare Job
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PhD and expertise in antibody/protein engineering. Design and execute protein and antibody discovery initiatives. Early discovery experience including phage display, affinity maturation, antibody humanization, and antibody optimization.
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As our biotech client continues to expand their Antibody Engineering group, we are seeking outstanding Antibody Engineers with strong phage display , molecular biology, and antibody engineering expertise.
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Expertise in protein and antibody modeling. As our biotech client continues to expand their Antibody Design group, we are seeking an outstanding AI Antibody Drug Designer. Successful contributions to therapeutic antibody programs.
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Biology/immunology background with a good understanding of fluorescent sorting and antibody staining techniques highly preferred. Must currently be enrolled as rising 3rd or 4th year undergraduate, or within 12 months of graduating from a BS or MS academic degree program at an accredited college or university, majoring in in biology, cell biology, microbiology, molecular biology, biochemistry, bioengineering, biotechnology, bioinformatics, or a related science.
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Immunoassay development, validation and sample analysis of PK/PD, Anti-Drug Antibody (ADA) and soluble protein biomarkers in support of biologic drug development in a GLP environment or similar.
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