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This position requires strong pharmacometrics skills combined with biological understanding and assay development skills to enable the team to conduct PK modeling studies. A deep understanding of PK and ADA assay development principles and techniques (ELISA, MSD, BLI, SPR, MS, %recovery) with precision and accuracy.
Full-timeExpandApply NowActive JobUpdated 11 days ago - UpvoteDownvoteShare Job
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Understand biological assay development needs and advise biologists on experiments required to validate biological assays for Drug Discovery programs. Leads the design and analysis of in-vitro and in-vivo experiments to advance the discovery portfolio in multiple therapeutic areas, innovative study designs, and statistical analysis plans in collaboration with biologists and other researchers.
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Demonstrated experience in design and interpretation of in vivo and/or in vitro biological experiments. Vesalius Therapeutics is seeking a highly motivated and collaborative Computational Biologist driven to leverage single-cell genomics data to reveal biological mechanisms of health and disease.
Full-timeExpandApply NowActive JobUpdated 26 days ago - UpvoteDownvoteShare Job
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Execute assays to assess gene and protein expression (e.g., qPCR, ELISA, Flow Cytometry, Fluorescence Microscopy), and biological effects (e.g., function, viability, enzymatic activity) in cell lines and primary and iPSC derived 3D organoid cultures.
Full-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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The Senior Research Associate/Associate Scientist will be a key contributor in our research efforts in delivering our novel gene writing technologies to target tissues *in vitro. Investigate the biological impact of non-vial delivery of gene writer systems *in vivo.
ExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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Research and optimize non-viral gene delivery of novel gene writing tools to modify target tissues and cells in vitro. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX.
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Interpret SAR and prioritize compounds for in vitro and in vivo biological and DMPK assessment. Interpret SAR and prioritize compounds for in vitro and in vivo biological and DMPK assessment.
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Expertise in advanced interdisciplinary systems such as optics, fluidics, and thermal management of biological samples. Knowledge of in-vitro diagnostics product development process. Comfort working in biological laboratories with a basic knowledge of wet lab instrumentation & equipment.
Full-timeExpandApply NowActive JobUpdated 11 days ago - UpvoteDownvoteShare Job
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This individual would own the implementation and execution of in vitro assay development and screening strategies, assist in lab automation, manage the lab operations and activities of junior level scientists and CROs, and contribute to progressing lead compounds through our drug discovery process.
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Prepare routine in vitro samples for metabolism identification studies including but not limit to incubation with hepatocytes, liver microsomes or other biological matrices. Perform in vitro and in vivo drug metabolism studies for discovery projects in various Sanofi R&D portfolios.
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Desired expertise in human cell cultures, organoids, Organ Chips, or other in vitro models, as well as biological and molecular assays. The research team focuses on the application of cutting-edge technologies in tissue engineering, microfluidics, and bioengineering to develop advanced in vitro models for studying urogenital and reproductive health and related disease.
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Candidates should have a B.S. or M.S degree in biological sciences (Molecular Biology, Biotechnology, Immunology, Biochemistry, or similar field) with at least 1 year of relevant laboratory experience.
Full-timeExpandApply NowActive JobUpdated 12 days ago - UpvoteDownvoteShare Job
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Postdoctoral Position in Microfluidic In vitro Models for Womens Urogenital and Reproductive Health Research. Postdoctoral Position in Microfluidic In vitro Models for Womens Urogenital and Reproductive Health Research.
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Ongoing projects include: ·In vitro analyses of protein interactions that modify the barrier. QualificationsQUALIFICATIONS:BS in biological/physical science required. In vivo determination of barrier loss and restoration effects on disease.
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A wide range of tools are used, including genetically-modified (knockout/transgenic) mice, patient biopsies, and cutting-edge microscopy approaches. The lab environment includes members from diverse backgrounds who collaboratively drive discovery and teach one another.
ExpandApply NowActive JobUpdated 16 days ago
vitro biological jobs in Watertown, MA
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