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The Senior Research Associate/Associate Scientist will be a key contributor in our research efforts in delivering our novel gene writing technologies to target tissues *in vitro. Investigate the biological impact of non-vial delivery of gene writer systems *in vivo.
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Work closely within DMPK, Cross functional groups and subject matter experts to ensure that in vitro/in vivo DMPK technologies and science are relevant for project teams and portfolio deliverables.
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Interpret SAR and prioritize compounds for in vitro and in vivo biological and DMPK assessment. Interpret SAR and prioritize compounds for in vitro and in vivo biological and DMPK assessment.
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The major focus of this position will be the in vivo evaluation of novel biological and small molecule therapeutic agents, including RNbased approaches that will support the drug discovery efforts across multiple programs form target validation to identification of clinical candidates.
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Interpret complex biological in vitro and in vivo data. Prior experience with high-throughput formulation screening in vivo and in vitro. Analytical assay development. Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time.
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We are seeking a Research Associate or Senior Research Associate Contractor who will be responsible for developing and performing in vitro studies for mechanism of action and efficacy of novel biological and/or small molecule therapeutic agents, including nucleic based approaches to support drug discovery efforts across multiple programs from target validation to human translation.
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Identify CRO resources, design and manage studies and establish strong capabilities in a completely outsourced setting, to design and execute in vitro assays and in vivo pharmacology studies. Ph. D. degree in Biological Sciences, Molecular Biology or Pharmacology or equivalent.
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Reporting to the Senior Staff Scientist and Director, you will support these studies, learn cutting edge in vitro and stem cell techniques, and contribute to developing new protocols for downstream analysis.
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Understand biological assay development needs and advise biologists on experiments required to validate biological assays for Drug Discovery programs. Leads the design and analysis of in-vitro and in-vivo experiments to advance the discovery portfolio in multiple therapeutic areas, innovative study designs, and statistical analysis plans in collaboration with biologists and other researchers.
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Research and optimize non-viral gene delivery of novel gene writing tools to modify target tissues and cells in vitro. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX.
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Execute assays to assess gene and protein expression (e.g., qPCR, ELISA, Flow Cytometry, Fluorescence Microscopy), and biological effects (e.g., function, viability, enzymatic activity) in cell lines and primary and iPSC derived 3D organoid cultures.
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The Group also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.
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This role is involved in all aspects of in vitro/in vivo neuromuscular disease biology, evaluating efficacy, pharmacodynamics, pharmacokinetics, and mechanisms of action of our therapeutic molecules.
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It is highly desired that you will have experience in applying diverse mass spectrometric workflows such as high-resolution and triple quadrupole mass spectrometry to characterize and quantify drug and its metabolites via in vitro and in vivo assays.
Full-timeExpandApply NowActive JobUpdated 12 days ago - UpvoteDownvoteShare Job
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This individual would own the implementation and execution of in vitro assay development and screening strategies, assist in lab automation, manage the lab operations and activities of junior level scientists and CROs, and contribute to progressing lead compounds through our drug discovery process.
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vitro biological jobs in Cambridge, MA
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