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Alloy’s Translational Research team supports our drug discovery partners with in vitro and in vivo testing of therapeutic drug candidates across multiple modalities. You have experience with primary human immune cell activation assays using multparameter flow cytometry.
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Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection, functional immune cell assays (proliferation, cytotoxicity, chemotaxis) and assay development is essential.
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Extensive hands-on experience with standard immunological techniques including multi-parameter flow cytometry, cell sorting, immunoassays such as ELISA, Cytotoxicity, in vitro co-culture assays (MLR, PBMC cultures, etc), and reporter bioassay development.
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Develop and validate immunological assays (, flow cytometry, ELISA, CyTOF, cytokine profiling) to evaluate drug candidates' efficacy and mechanism of action. Learn more about Flagship at Position Overview:We are seeking a highly skilled PhD level Principal Scientist with proven experience in immunology and preclinical research to join our team.
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Experience in flow cytometry, microbiology, PCR and ELISA testing is a plus. Demonstrate basic knowledge of the GXP cellular therapy product manufacturing, and program development and evaluation, as well as needs assessment and marketing of the programWorking knowledge of flow cytometry, molecular biology, and genetic engineering is a plus.
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Expertise in at least one of the following assay methods: ELISA, Western blot, qPCR, flow cytometry, ChIP. Implement target-specific assays to assess target and drug activity in vitro and/or in vivo, as appropriate.
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Under the general supervision of the investigator, performs complex laboratory experiments in the field of cell biology including: cell culture, ELISA, DNA/RNA isolation, PCR, general biochemistry, immunohistochemistry, flow cytometry, and microscopy.
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HER2 FISH, immunofluorescence microscopy and flow cytometry are performed on-site. Lahey Hospital and Medical Center values research and education as evidenced by renowned internal programs and an exciting new affiliation with UMass Chan Medical School.
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Hands-on experience in tissue culture, plate-based assays, RNA isolation, gene expression analysis (qPCR), western blot, ELISA, multiplex protein analysis, flow cytometry preferred. PepGen's Enhanced Delivery Oligonucleotide, or EDO, platform is founded on over a decade of research and development and leverages cell-penetrating peptides to improve the uptake and activity of conjugated oligonucleotide therapeutics.
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Performing in vivo catheterizations for measurement of vascular and chamber pressure in cardiovascular rodent models. Communicating, collaborating and consulting with veterinarians, peers and scientific investigators on best practice, optimization and production of in vivo, surgical models.
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Experience with flow cytometry, immunofluorescent imaging, confocal microscopy, ELISAs, and PCR.· Experience with microfluidics, bioprinting, and/or related microfabrication techniques is a plus.
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Strong knowledge of biomarker technologies and methodologies, including genomics, proteomics, imaging, and flow cytometry, as applied to clinical research. or equivalent degree in Molecular Biology, Biochemistry, Pharmacology, or related field with a minimum of 8 years of relevant experience in clinical biomarker research within the biopharmaceutical industry.
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Position SummaryThis position is a key leadership role for the development of the In Vivo franchise at CRISPR. Reporting to the Senior Director of Regulatory Affairs CMC, you will work closely with cross-functional teams and partners to bring multiple novel therapies to patients.
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Our portfolio, spanning from in-vitro and in-vivo diagnostics to image-guided therapy and innovative cancer care, is crucial for clinical decision-making and treatment pathways. PhD in mechanical engineering or mechatronics or closely related fields (preferably with research background in the field of medical device.
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This is a chance to connect with us and showcase your skills for current or upcoming positions in our Research Associate community. Utilizes other protein biochemistry and proteomic techniques such as western blotting, multidimensional chromatography and in-gel digestion to meet project and research goals.
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vivo flow cytometry research associate jobs in Waltham, MA
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