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Lead single-cell RT-PCR, PCR, molecular cloning, and BCR sequence analysis to best harvest variable antibody regions for expression, NGS and/or repertoire cloning into in vitro display platforms, with associated analysis and management of data.
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You will develop novel bioinformatics and machine learning solutions and apply them to next-generation sequencing (NGS) data to discover and characterize biotherapeutics. + In-depth experience analyzing NGS data including B-cell receptor and antibody repertoire sequencing data.
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DNA characterization and quality control testing using techniques such as gel electrophoresis, RNaseA testing, nanodrop, PCR, and preparation of samples for sequencing analysis (Sanger and NGS.
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Proven experience working with complex matrices and cell isolation, ideally also exposure to technologies required for cell and gene therapy products such as NGS, PCR variations including ddPCR, flow cytometry.
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In addition to strong diagnostic skills in surgical pathology, expertise in molecular diagnostics (including NGS and FISH) is desirable. Board certification in Molecular Pathology (including NGS) is a significant plus.
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Our research team is based at the Broad Institute of MIT and Harvard, with members in the Data Sciences Platform, Program in Medical and Population Genetics, and Stanley Center for Psychiatric Research, and in the Center for Genomic Medicine (CGM) at Massachusetts General Hospital (MGH) and Harvard Medical School.
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Independently design, execute and troubleshoot various biochemical and cell-based assays to further the company’s understanding of oligo-directed RNA editing including, but not limited to enzyme kinetics, protein purification, protein binding assays (SPR, fluorescence polarization), structural biology, molecular modeling, SHAPEmap and RNA folding, LC-MS, cell-based assays, RNA isolation, Western blotting, qPCR, dPCR and NGS.
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Our laboratory utilizes biochemical, cellular and mouse modeling approaches to elucidate mechanisms that drive cancer.
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The Tufts Department of Biology has diverse research interests and is engaged in cutting-edge biological research in molecular biology, genetics, cell biology, neurobiology, physiology, plant ecology, animal behavior, and conservation biology.
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The molecular tests include a next generation sequencing (NGS) solid tumor DNA test (the first and currently only NGS program in the BILH health system). The molecular tests include a next generation sequencing (NGS) solid tumor DNA test (the first and currently only NGS program in the BILH health system.
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Strong preference for advanced scientific degree (Ph. D. or Master’s) in molecular biology, cell biology, biochemistry, chemistry, immunology, genetics, structural biology, or related field. About You:J.D. degree or LL.M. degree from an accredited law school, admission to practice law in a U.S. jurisdiction, and at least four years' experience as a patent agent or patent attorney registered to practice before the U.S. Patent and Trademark Office.
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Position is ideal for those experienced and/or have a strong interest in stem cell biology, disease modeling, neurobiology and developmental genetics. Additionally, bench-level experience in biochemical assays such as Western analysis, PCR and RT-PCR, immunohistochemistry, ELISA, luminescence, etc.
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Medical doctor (MD) and/or PhD in Biochemistry, Molecular Biology, or Genetics. The Director, Companion Diagnostic Lead (CDxL) will be responsible for the execution of global Diagnostic strategies within the Bayer Precision Medicine driven portfolio of products.
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Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders.
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The Research Technician will help organize and maintain a research laboratory, and participate in research studies focused on understanding the molecular mechanisms regulating Small RNA and RNAi function using genetics, molecular biology, cell biology, and biochemical procedures.
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ngs genetics jobs in Waltham, MA
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