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A minimum of 10 years of related pharmaceutical or biotechnology industry experience in clinical pharmacology, population PK, PK-PD modeling, DMPK, and/or pharmacometrics and a proven track record advancing programs through the drug development process, from discovery through IND to registration, informing data driven decisions on dose and schedule, making tough judgement calls where needed.
ExpandApply NowActive JobUpdated 14 days ago - UpvoteDownvoteShare Job
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Serve as the subject matter expert on cross-functional teams to lead projects, direct GLP bioanalytical validations and sample analysis across all nonclinical, DMPK and clinical pharmacology development.
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Collaborate with high throughput biology, cell modeling, medicinal chemistry, and in vivo pharmacology to advance projects from hypothesis to IND-enabled programs. Flow cytometry experience preferred.
ExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Act as the lead clinical pharmacologist on clinical pharmacology study teams to support clinical development: independently lead the design, protocol development, execution, analysis, and reporting of clinical pharmacology studies (e.g., food effect, BA/BE, human ADME, drug interactions, renal and hepatic impairment, etc.
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Global Discovery and Development Sciences (GDDS) Boston, part of the US R&D hub, is building a new siRNA Nonclinical Development department with cross-functional scientific expertise, including toxicology, safety pharmacology, PKPD, ADME, outsourcing management, and non-clinical project management.
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The Program Leader will lead a cross-functional team across clinical operations, regulatory affairs, clinical pharmacology, biomarkers, CMC, non-clinical, and medical to deliver against the program strategy.
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Proficiency in mammalian cell culture techniques, flow cytometry, qPCR, DNA and RNA extraction, transfection, ELISA, and western blotting. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX.
ExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Experience with primary cell culture, assay development, qPCR, multicolor flow cytometry. Experience with primary cell culture, assay development, qPCR, multicolor flow cytometry. PhD in molecular biology, cell biology, biochemistry, immunology, stem cell biology or related field with 0-2 years experience; or MS in molecular biology or related field with 3-5 years experience.
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Real-time flow cytometry is performed on-site by dedicated flow cytometry technicians and hematopathologists. The Palliative Care Service, Behavioral Oncology, the Survivorship Program, social workers and an acupuncturist provide additional imbedded complementary and supportive care for our hematology patients.
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Support flow cytometry evaluation of RNA nanoparticles. The successful candidate will have a strong hands-on background in wet lab biology to support nanomedicine-related research including but not limiting to nanoparticle formulation, flow cytometry, molecular endpoints, bioconjugate chemistry, in vitro assays, gel-based characterization and cell-based assays.
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Perform cell type differentiation, characterization and experimental endpoint analysis including flow cytometry, ELISA and microscopy. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor George Church’s lab, a pioneer in synthetic biology, and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency and speed.
ExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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Direct experience with flow cytometry, and cell-based assay characterization is a requirement. The ElevateBio ecosystem combines multiple R&D technology platforms – including Life Edit, a next-generation, full-spectrum gene editing platform; comprehensive cell engineering technologies; and an expanded viral and non-viral therapeutic delivery platform – with BaseCamp, its end-to-end genetic medicine cGMP manufacturing and process development business, to accelerate the discovery and development of advanced therapeutics.
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Imaging/ multicolor flow cytometry-based instruments and data analysis programs. Tissue culture techniques and functional cell-based assay development. Ph. D. in Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with 5+ years of experience in antibody engineering and/or bispecific design.
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Support DMPK needs for clinical stage programs through close collaboration with Clinical Pharmacology and Toxicology. Work closely with DMPK CROs to design, coordinate, monitor and manage external ADME and PK studies.
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Develop and implement an integrated medicinal chemistry strategy, working in concert with partners in Data Science, De Novo Discovery, Molecular and Cellular Biology, DMPK and Pharmacology to reach hit-to-lead and lead optimization goals.
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histologist cytometry pharmacology jobs in Lexington, MA
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