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Principal Associate Scientist / Senior Principal Associate Scientist, Hit Identification And Biology
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In addition, the candidate will assist the flow cytometry core manager with daily operations and maintenance. Experience with flow cytometry, cell sorting, and analysis of flow cytometry data is preferredStrong organizational and time-management skillsExcellent verbal and written communication and interpersonal skills to work across functionsAbility to work within a team, coordinating with other scientistsSelf-motivated, conscientious, and enthusiastic about helping patients.
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Act as the lead clinical pharmacologist on clinical pharmacology study teams to support clinical development: independently lead the design, protocol development, execution, analysis, and reporting of clinical pharmacology studies (e.g., food effect, BA/BE, human ADME, drug interactions, renal and hepatic impairment, etc.
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Strong knowledge of pharmacokinetics and pharmacodynamics principles, immunogenicity, modelling and simulation, Model-Informed Drug Development, ADME Concepts, and regulatory clinical pharmacology requirements to support clinical development and regulatory submission.
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Global Discovery and Development Sciences (GDDS) Boston, part of the US R&D hub, is building a new siRNA Nonclinical Development department with cross-functional scientific expertise, including toxicology, safety pharmacology, PKPD, ADME, outsourcing management, and non-clinical project management.
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Participate in the construction and screening of immune-based libraries through immunization, antibody display, and flow cytometry. Provide assistance in the execution of experiments and analytical procedures including: molecular biology, DNA cloning, cell culture, protein production, ELISA, Biolayer interferometry and HPLC.
$78,000 - $83,500 a yearFull-timeExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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They will drive scientific, technical, and executional excellence in the development and technology transfer of assays (immuno-, molecular, cytometry, and cell-based assays) used in the characterization and quality control of our TCR T cell therapy products and intermediates.
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The candidate should possess an in-depth understanding of safety pharmacology, investigative and regulatory toxicology, and have experience designing and critically evaluating results of exploratory and GLP-compliant toxicology studies.
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Proficiency in a variety of bioanalytical techniques including, but not limited to, ELISA, MSD, HTRF, flow cytometry, qPCR, NGS, mass spectrometry, and cellular imaging techniques. Key Responsibilities: Lead biology, assay development and in vitro pharmacology activities, serving as a pivotal functional representative on program teams and spearheading platform development initiatives.
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Job Overview: This role, for a Document QC Specialist Contractor, will manage the quality control of scientific documents and Bioanalytical data for the Translational DMPK and Clinical Pharmacology group.
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Partners with CMC, Clinical Development, Clinical Operations and Pharmacology to ensure GMP, GLP and GCP compliance for all clinical development programs by providing guidance. Oversees the QA reviews of GMP manufacturing batch records, product release and stability testing, validation reports, pharmacology and toxicology study reports and essential clinical study documents.
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Performs routine experiments including flow cytometry. The Jain Laboratory at the Mucosal Immunology and Biology Research Centre (MIBRC) and MGH is focused on approaches that integrate advanced cellular, computational and molecular methods to understand the mechanisms of microbial influence on postnatal immune system development.
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The applicant is expected to develop highly effective collaborations with relevant stakeholders including those in Patient Health & Impact, the Patient-Centered Outcomes Assessment Group, Statistics, Clinical Pharmacology, Clinical Development, Medical Affairs, Epidemiology, Programming, and other groups contributing to HEOR analysis and strategy.
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Provides scientific and clinical input to study-related documents and analysis plans including Informed consent forms (ICF), clinical research forms (CRF), statistical analysis plans (SAP), clinical pharmacology and biomarker analysis plans.
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PhD or equivalent degree in pharmacology, pharmaceutical sciences, biology, or related field with a minimum of 6 years of leadership experience in in vivo pharmacology within the context of LNP drug delivery.
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The primary focus of this position will be on ensuring Good Laboratory Practice (GLP) and ISO conversion for a team dedicated to assisting cancer patients using various molecular techniques, including MXIF, IHC, Flow cytometry, and DNA and RNA sequencing (exome.
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histologist cytometry pharmacology jobs in Burlington, MA
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