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Operate and maintain automated liquid handlers for plasmid purification, as well as downstream QC applications like NGS and DNA normalizations. Job Title : Bench Scientist. Conducting routine molecular biology techniques including cell transformations, day cultures, bacterial cultures, Gibson assembly, and digestions.
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This position is a hands-on role, and the successful candidate will have deep knowledge and experience in long oligonucleotide purification and downstream processing to advance our cutting-edge gene editing drug discovery programs.
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Job Description: BioMedicine Design (BMD) is seeking a highly motivated Biochemist/Molecular Biologist to join Biotherapeutic Expression and Purification group (BEP) in Cambridge, MA. Qualified candidate will play an essential role in a high-energy DNA production and protein expression research laboratory.
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Downstream experience with standard chromatography and/or DNA purification kits is a plus. The Research Production team is responsible for the upstream enzymatic synthesis and downstream manufacturing of drug substance to support pre-clinical trials.
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Generation Bio seeks an energetic, highly motivated, and dynamic principal associate scientist to support daily operations within the Research Production team. We are seeking motivated individuals with experience and familiarity with enzymatic synthesis, standard chromatography techniques, TFF, DNA purification kits, and molecular biology techniques such as DNA manipulations including PCR, ligations, restriction digestions, and plasmid cloning.
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Principal Scientist, Protein Production and Process Development. and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development. The Principal Scientist will engage a diverse team of research associates and scientists focused on production of lead TCR bispecific molecules and optimization of processes.
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As a Research Associate, Molecular Biologist, you will report to the Principal Scientist - Cell Characterization to perform the collection and quality control analysis of cell samples for genomic and epigenomic assays, as part of Sana's Cambridge Stem Cell Sciences group.
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Conducts radioligand binding, biochemical and cell-based signaling assays to support the Internal Medicine Research Unit, including in vitro and ex vivo experiments to help characterize novel targets, characterize target engagement and downstream effects of small molecule modulators.
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Extensive experience with molecular biology techniques as related to cell and tissue culture, preparation of brain samples for downstream mass spectrometry proteomics analyses. We are looking for a Scientist who has a strong expertise and background in preparing samples from human brain tissue for mass spectrometry proteomics analysis.
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Proficiency in tissue culture and downstream molecular biology techniques is required. The position will assist in biology assay development for both early and late-stage research programs focused on neurobiology and immunology drug discovery.
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Immediate Opportunity: Bench Scientist located in Cambridge, MA (Onsite). Conducting routine DNA characterization and quality control testing using techniques such as gel electrophoresis, fragment analysis, nanodrop, endotoxin testing, and preparation of samples for sequencing analysis (Sanger and NGS.
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We are looking for a scientist that possesses a strong background in chemistry or related scientific fields, hand-on experience in oligonucleotide analytical techniques, along with a willingness to learn and collaborate in a fast-paced environment.
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Conduct routine in vitro transcription reactions and subsequent downstream purification steps as necessary. The ElevateBio ecosystem combines multiple R&D technology platforms – including Life Edit, a next-generation, full-spectrum gene editing platform; comprehensive cell engineering technologies; and an expanded viral and non-viral therapeutic delivery platform – with BaseCamp, its end-to-end genetic medicine cGMP manufacturing and process development business, to accelerate the discovery and development of advanced therapeutics.
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We are seeking a talented and highly motivated Sr. Associate Scientist in molecular biology and metabolism to support our drug discovery programs. Supervise the execution of pharmacology studies at CROs and perform in-house downstream analysis to support drug discovery program needs.
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Additional skills to support downstream characterization as needed would be beneficial and could include: protein expression and purification using FPLC systems and biophysical characterization methods (SEC-MALS, DSF, and biosensor techniques including BLI and SPR.
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downstream scientist jobs in Lexington, MA
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