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Comprehensive understanding of immune response to viral and non-viral vectorsExpertise: In-depth knowledge of molecular biology, DNA engineering, and plasmid-based technologies. This is what you will do: As the Director of Vector Engineering and Immunogenicity Reasearch at Alexion, AstraZeneca Rare Disease, Genomic Medicine Department, you will lead AAV vector research and development with a focus on therapeutic transgene plasmid design, and oversee immunogenicity assessments.
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Your work will be instrumental in building and optimizing a molecular instruction set that enables the world’s first DNA storage and computing platform. CATALOG, a Boston-based pioneering startup, is a leader in the field of data storage and computation by harnessing the power of DNA. DNA, known for its millennia-long stability, unrivaled information density, and cost-effective replicability, offers revolutionary potential for latency-tolerant high-density data storage and massively parallel computation.
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Designing, training and fine-tuning deep learning models to engineer proteins, RNA or DNA. You will be part of an agile, cross-functional team responsible for generating protein, RNA or DNA sequences, updating models with experimental data, and integrating ML models into the data pipelines for our labs.
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Illustrative subject matter concerns patent prosecution and counseling projects with emerging companies focused on antibodies, DNA or RNA therapeutics, chemical biology, gene-editing, etc. Our firm is Seeking a midlevel associate with 1-5 years of patent prosecution experience in a biotechnology practice and an advanced degree, preferably a Ph. D., in a life sciences technology area, e.g. molecular biology, immunology, biochemistry, cell biology, and the like.
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Job Description: BioMedicine Design (BMD) is seeking a highly motivated Biochemist/Molecular Biologist to join Biotherapeutic Expression and Purification group (BEP) in Cambridge, MA. Qualified candidate will play an essential role in a high-energy DNA production and protein expression research laboratory.
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Examples of laboratory tests performed by Clinical Laboratory Scientists includes detection of abnormal cells causing leukemia, analysis of cardiac enzyme activities, identifying type of bacteria causing an infection and detection of DNA markers for genetic diseases.
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Under the general supervision of the investigator, performs complex laboratory experiments in the field of cell biology including: cell culture, ELISA, DNA/RNA isolation, PCR, general biochemistry, immunohistochemistry, flow cytometry, and microscopy.
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Experience with molecular biology techniques such as gel electrophoresis, PCR, DNA purification, adapter ligation, bead-based clean up, and/or sequencing. Experience with molecular biology techniques such as gel electrophoresis, PCR, DNA purification, adapter ligation, bead-based clean up, and/or sequencing.
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Familiarity with purification of DNA and RNA. Experience with oligonucleotide enzymatic and/or chemical synthesis, basic nucleic acid biochemistry and molecular biology is preferred. We are seeking a part-time Senior Research Associate/Associate Scientist, Nucleic Acid Process Sciences.
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Scientific training and hands-on experience with various cell-based and molecular assays, including but not limited to 2D and /3D cell culture, cell-based potency assay, ELISA, western, qPCR, RT-qPCR, and DNA/RNA/protein extraction from cells and animal (including NHP) tissues.
$61.28 - $66.28 an hourExpandApply NowActive JobUpdated 29 days ago - UpvoteDownvoteShare Job
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The teacher must be confident and comfortable in a wet lab space teaching students about the basics of laboratory research and current laboratory techniques such as gel electrophoresis, DNA extraction, PCR, and ELISA. In addition, the teacher will be responsible for ordering reagents and materials, preparing experimental protocols, and setting up the equipment for each session.
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Design and execute experiments using standard molecular biology techniques including PCR, cloning, DNA purification, and preparation of NGS samples from various display libraries. Design and execute experiments using standard molecular biology techniques including PCR, cloning, DNA purification, and preparation of NGS samples from various display libraries.
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At least 5+ years of hands-on industry and/or academic experience with next-generation DNA sequencing (NGS) and associated methodologies including DNseq and/or RNseq protocols. At least 5+ years of hands-on industry and/or academic experience with next-generation DNA sequencing (NGS) and associated methodologies including DNseq and/or RNseq protocols.
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PhD or equivalent with 1 to 3 years, or MS with 3 to 5 years of experience on assay development, AAV experience strongly preferred. Develop, optimize, and execute bioanalytical assays to characterize AAV vectors designed for various therapeutic programs and to evaluate PK/PD profiles of such vector in appropriate model systems.
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Experience with a variety of molecular and cell biology techniques such as DNA/RNA/protein extraction, cloning, sequencing, PCR, qRT-PCR, ddPCR, ELISA, Western blot. Experience with a variety of molecular and cell biology techniques such as DNA/RNA/protein extraction, cloning, sequencing, PCR, qRT-PCR, ddPCR, ELISA, Western blot.
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dna job in Cambridge, MA
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