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Key Responsibilities of a Process Development Engineer: Design and development of equipment, processes, and control systems, used for production and assembly of cell encapsulation devices.
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The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery and process development groups.
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We are seeking a highly motivated and experienced Upstream Process Development Scientist with a strong background in viral vector production to join our dynamic team. A minimum of 3-5 years of experience in upstream process development, with a focus on viral vector production.
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High level of expertise in stem cell biology, process engineering, and project management, ensuring the successful development and implementation of cell therapy manufacturing processes.
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Research Associate/Senior Research Associate, Process Development. Execute experiments to support Cell Line Development and Scale up of PSC-derived cells. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor George Church’s lab, a pioneer insynthetic biology, and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency, and speed.
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Director/Sr. Director - Process DevelopmentGreater Boston Area Competitive Compensation + excellent bonus/benefitsDuties and Responsibilities:Lead all process development activities (cell culture/banking/development, fermentation, protein purification, tech transfers)Oversee internal(in-house) and external vendors (domestic & international CDMOs)Work cross-functionally with CMC & Manufacturing leaders such as Analytical, Drug Product, QA/QC, Manufacturing, Supply Chain, etc.
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The pilot plant also provides critical technical support for technology transfers, process development, and scale-up / scale-down activities. The pilot plant delivers data and material to support process development of early and late stage clinical biologic molecules.
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Qualified candidates must have a PhD in synthetic/organic chemistry or related scientific field with 15+ years’ experience in drug substance development and manufacturing and a proven track record in developing and scaling up chemical process to kilo lab, pilot plant and commercial plant scales.
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Experience with standard molecular biology techniques such as nucleic acid isolation, purification and quantitation, bioanalyzer, DNA/RNA quantitation, qPCR or Next Generation Sequencing. This position is involved in all aspects of assay automation development and instrument integration.
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As a member of the Arcaea team, you will be responsible for leading Arcaea's downstream process development and scaling up activities. Conduct hands on troubleshooting, process feasibility and process optimization experiments in relation to downstream purification and recovery processes.
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Work with supervisor and colleagues to obtain exclusive training for Microscoop system hardware, software, kits, peptide purification, and initiation of proteomics analysis, focusing on microscopy-guided proteomics applications, sample preparation techniques, and image analysis methodologies.
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Execute molecular biology assays, including PCR, gel electrophoresis, DNA purification and quantification. The company’s early scientific team will play a leading role to translate the technology, define the early clinical pipeline, develop the scientific strategy for key preclinical experiments, and work at the forefront of gene editing therapeutic development.
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The Senior Principal Scientist role will include leading a multidisciplinary team of chemists and chemical engineers in the development of efficient and sustainable manufacturing processes for peptide synthesis and purification, driving technology innovation in the areas of chemical and microbial recombinant peptide production technologies, and providing technical expertise as well as developing and mentoring staff within the organization.
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The Business Process Manager will play a key role in facilitating communication between IT and functional teams and will work with multiple teams to provide systems analysis for business processes.
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The candidate will be a motivated and curious researcher, with willingness to learn about numerous areas of oligonucleotide synthesis and purification. The individual will contribute to the development of our new drug delivery platform and to our clinical program pipeline.
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process development purification jobs Company: Abbvie in Boston, MA
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