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Maintain a log sheet for all in-process sample analysis; help to manage consumables and parts for in-process analytics and downstream purification. Prime Medicine is seeking an Associate Scientist I/II in oligonucleotide analytical chemistry to join our gRNA process chemistry team.
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Expertise in reverse phase UV-triggered/Mass-directed HPLC chromatography for purification of peptides/peptide conjugates in milligram/multi-milligram amounts, in support of internal discovery efforts.
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Collaborate with process development scientist to get trained and transfer new processes into cGMP manufacturing. Duties include basic cell culture as well as specialized techniques for cell selection, activation, transduction, and purification.
$84,000 - $132,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Experience with standard molecular biology techniques such as nucleic acid isolation, purification and quantitation, bioanalyzer, DNA/RNA quantitation, qPCR or Next Generation Sequencing. Establish user requirements associated with the design of new production lines including individual pieces of laboratory equipment and process workflow equipment.
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Work with supervisor and colleagues to obtain exclusive training for Microscoop system hardware, software, kits, peptide purification, and initiation of proteomics analysis, focusing on microscopy-guided proteomics applications, sample preparation techniques, and image analysis methodologies.
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Execute molecular biology assays, including PCR, gel electrophoresis, DNA purification and quantification. Assist in mRNA synthesis, purification, and quality assessment. The company was founded by world leading CRISPR, gene editing, and molecular biology pioneers from MIT, Broad Institute, Harvard and Duke Universities and world-class investors using a novel targeted cell and gene therapy platform.
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Conceptual understanding of solid phase oligonucleotide synthesis and purification strategies. The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery and process development groups.
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Operations will include scale up, bioreactor support, process monitoring, chromatography, various types of filtration, ultrafiltration/diafiltration and equipment cleaning. Experienced in performing bioprocess unit operations in cell culture and/or purification.
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Director/Sr. Director - Process DevelopmentGreater Boston Area Competitive Compensation + excellent bonus/benefitsDuties and Responsibilities:Lead all process development activities (cell culture/banking/development, fermentation, protein purification, tech transfers)Oversee internal(in-house) and external vendors (domestic & international CDMOs)Work cross-functionally with CMC & Manufacturing leaders such as Analytical, Drug Product, QA/QC, Manufacturing, Supply Chain, etc.
$210,000 - $240,000 a yearExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The Business Process Manager will play a key role in facilitating communication between IT and functional teams and will work with multiple teams to provide systems analysis for business processes.
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The candidate will be a motivated and curious researcher, with willingness to learn about numerous areas of oligonucleotide synthesis and purification. The successful candidate will contribute to the synthesis, purification and characterization of oligonucleotides to support our research platform.
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Key Responsibilities of a Process Development Engineer: Design and development of equipment, processes, and control systems, used for production and assembly of cell encapsulation devices. General Summary of a Process Development Engineer: This role will focus on the development of implantable cell encapsulation devices for delivering proprietary cells.
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Experience with RNA biochemistry, synthesis, purification, characterization, and structural evaluation with techniques including crystallography, SHAPE-MaP, or NMR is preferred. You have an understanding of protein expression and purification.
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We are seeking a highly motivated and experienced Upstream Process Development Scientist with a strong background in viral vector production to join our dynamic team. A minimum of 3-5 years of experience in upstream process development, with a focus on viral vector production.
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High level of expertise in stem cell biology, process engineering, and project management, ensuring the successful development and implementation of cell therapy manufacturing processes. Oversee and perform routine stem cell culture, expansion, and differentiation of pluripotent stem cells to aid in process development, enhancement, and evaluation.
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process purification jobs Company: Abbvie in Boston, MA
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