Senior Scientist, Allogeneic T-Cell Therapy Process Development

Overview In this role you drive development of clinical manufacturing processes for allogeneic CAR-T and TCR-T products. You will work within the Allogeneic T-Cell Therapy Process Development team to optimize and characterize processes and support tech transfer to cGMP operations. You’ll apply strong scientific judgment to scale up and improve culture, gene editing, and characterization methods, collaborating across functions to enable clinical manufacturing readiness. This is a hands-on, impact-oriented position with opportunities to mentor others and contribute to regulatory and development documentation. You join a mission-driven, collaborative environment that values innovation and patient impact Compensation / Benefitsannual base payshort-term incentive bonusesequity-based awardsretirement programspaid time offhealth, dental, and vision coverage ResponsibilitiesHands-on cell culture work with human CAR-T and TCR-T cells: generation, expansion, and characterizationPerform gene editing and manipulation of human primary cells to support process optimizationLead design, execution, analysis, and documentation of process development studies with minimal supervisionGuide data-driven decisions to advance scalable manufacturing approachesCollaborate cross-functionally with Process Development, Analytical Development, Manufacturing, Quality, and Regulatory to support tech transfer and clinical readinessAssist tech transfer activities: batch records and SOP development, real-time troubleshooting, deviations investigations, change control, process monitoring, and risk assessmentsContribute to development reports, scientific publications, patents, and regulatory filingsMentor junior scientists and associates to strengthen technical capability and executionTravel domestically and internationally as needed Key requirementsExperience culturing human primary cells (T cell culture essential)Knowledge of upstream and downstream process development for cell therapies, including tech transferStrong flow cytometry characterization of T cellsExperience engineering cells in scale-up with genome editing tools and DNA/RNA transfectionFamiliar with DOE fundamentalsStrong experimental design and data analysis skillsCritical thinking, analytical mindset, troubleshooting abilityExcellent teamwork and technical writing; weekend work possibleteamworkclear communicationmentoring and leadershipT cell cultureCAR-T and TCR-T developmentgene editing (CRISPR/Cas9, base editing)