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About Charles River Cell Solutions Charles River Cell Solutions is a global leader and trusted brand in the customization of human-derived biological products and services for biomedical research, drug discovery, and cell and gene therapy development.
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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.
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You will implement machine learning and computational chemistry-based methods to elucidate novel mechanisms of action for small molecule drug discovery. At Genentech Computational Sciences (gCS) Prescient Design, we are seeking a highly motivated Machine Learning Scientist to help drive research on Machine Learning for Drug Discovery.
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Contribute to the development of automated workflows to support assays such as immunoassay (IA), peptide stability, protein binding, automated sample preparation for plasma and tissue drug concentration analysis, cell culture maintenance & cell-based assays.
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Working knowledge of NGS methods used in research, with experience using liquid handling and automation being preferable (HTS, Assay Development, or molecular or structural biology backgrounds will also be considered) Experience with workflow optimization in genomics, drug discovery, and structural biology.
$120,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Responsibilities:We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets.
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Quantitative Systems Pharmacology (QSP) & Physiologically Based Pharmacokinetics (PBPK) have become important components of discovery and clinical development. + Assist therapeutic area expert modelers to accelerate efforts and ensure timely model development and calibration to impact drug development programs and coordinate technology development.
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Collaborate to identify, evaluate, and recommend novel and cutting-edge automation and assay strategies to drive our discovery programs, including machine learning and artificial intelligence. The Scientist will work collaboratively with other team members in a fast-paced environment to operate automated laboratory equipment and systems to support various DMPK assays.
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Responsibilities -Develop assays for GMP release of gene therapy products-Develop assays for product characterization of gene therapy products-Develop assays for AAV/protein/DNA to assist in evaluation of process change, formulation andstability study-Report project status (development plans, timelines, and results) to supervisor and technical teams.
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With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.
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Education and Knowledge, Skills and Abilities Required: Registration or Certification with Drug and Alcohol Certification recognized by ADP. 1 year or more experience working in a childcare environment or bachelor's degree in early childhood development.
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You are well versed in Development software tools: WordPress open-source platform, Hootsuite, Salesforce, Classy, Predictive Response, MailChimp, Canva, Adobe Creative Suite, media monitoring tools, web analytics tools and software, search engine optimization techniques, all preferred.
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The Associate Director of Radiopharmaceutical Process Development will be executing the CMC development plan and IND enabling activities, leading to the clinical manufacturing of the Drug Product.
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We seek creative, innovative scientists who define and address fundamental questions in transmembrane signaling biology, including basic and applied biochemistry, structural biology, cell biology and drug discovery.
$309,800 a yearFull-timeExpandApply NowActive JobUpdated 1 month ago
drug development discovery jobs Company: Advanced Clinical in South San Francisco, CA
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