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Familiarity with in vivo pharmacology, single cell workflows, and spatial omics would be helpful. This is a hands-on, lab-based position in which you will design, perform, and analyze in vitro and ex vivo experiments to validate biological and therapeutic hypotheses derived from clinical biomarker data, real-world data, and other sources.
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Provide bioanalytical support for PK, non-GLP toxicology and in vitro/in vivo PK-PD efficacy studies. Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples.
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Represent CMC, act as the liaison to partner with research radiochemistry and in-vivo team to share best practices and facilitate knowledge exchange. Represent CMC, act as the liaison to partner with research radiochemistry and in-vivo team to share best practices and facilitate knowledge exchange.
$185,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The successful candidate will contribute to the design and synthesis of novel chemical entities optimized for potency, selectivity, physicochemical properties pharmacokinetics and in vivo efficacy.
$120,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company's ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing.
$260,000 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The ocular group in Translational Immunology Department is seeking a motivated and flexible Research Technician Contractor to assist with in vivo animal studies and in vitro characterization of preclinical endpoints.
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With a solid in vivo experience and rodent handling, the successful candidate will assist with studies that require in vivo multimodal imaging (OCT, fundus, angiography), measuring retinal function (ERG, pERG, VEP) and behavioral testing.
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In this position, the successful candidate will enable in vivo research in the Cancer Immunology and Cell Therapy, Oncogenesis, Cardiovascular, and Discovery Biotherapeutics Thematic Research Centers.
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Understanding of general in vivo AAV pharmacology and toxicology best practices. Understanding of general in vivo AAV pharmacology and toxicology best practices. Leveraging and harnessing AGT core competencies in AAV gene therapy, the Nonclinical Studies Manager will be responsible for executing the AGT strategy in several disease indications.
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We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
$314,000 a yearFull-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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Your responsibilities will include phenotypic assay development, establishing pre-clinical in vitro/in vivo studies, performing mechanistic studies on lead drug molecules, spearheading forays into new oncology indications, and grant writing.
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In vitro work includes a range of cellular assays, cell culture including multiparametric flow cytometry and molecular biology techniques to help interpret in vivo observations. skills: Molecular Biology, Cell Biology, Biology, GLP (Good Laboratory Practice), In Vivo, Flow Cytometry.
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Primary Job Responsibilities:Manage mouse tumor projects, analyze data, and prepare presentations for Translational Medicine Perform animal handling, dosing, and necropsies for in vivo studies in the Vivarium Lab Keep detailed experiment records, analyze basic data, and follow strict lab protocols.
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Responsibilities:We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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The selected candidates will perform in vitro and in vivo studies of tumor metabolism, immunology and proliferation using methods such as cell culture, western blotting, flow cytometry, qPCR, intracranial tumor implantation, bioluminescence and MRI. The candidates will also optimize and validate novel metabolic imaging biomarkers using techniques such as 1H-, hyperpolarized 13C-, and deuterium magnetic resonance spectroscopy (MRS.
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vivo job in South San Francisco, CA
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