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ResponsibilitiesExtract protein, DNA and/or RNA from necropsied animal tissueRun ddPCR, qPCR, ELISA, Western Blot etc analysis on tissue extractsCell culture, Neutralizing antibody assays and total antibody assaysSample analysis assay optimizationSOP writingData recording and analysisQC analysis This position directly impacts preclinical outcomes including proof of concept, ED50, MED, clinical hold response and IND enabling studies.
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Analyze gene and protein expression through the application of a variety of techniques (RT-PCR, qPCR, digital PCR, western blot, immunofluorescence, and ELISA) Demonstrated experience with routine molecular biology techniques (DNA/RNA/protein isolation, cDNA synthesis, RT-PCR, qPCR, digital PCR, western blot, and immunofluorescence.
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Experience with in-vitro ELISA or activity assays is a plus. Primary Responsibilities: Primary contributor with protein characterizing mass spectrometry experiments, including maintaining the instrument, developing and performing experiments with an emphasis on intact mass, glycan analysis and peptide mapping studies.
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This role will support chromatography assay development for monoclonal antibodies, bispecific antibodies, cytokines, and antibody drug conjugates. This role will support chromatography assay development for monoclonal antibodies, bispecific antibodies, cytokines, and antibody drug conjugates.
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Broad practical experience with or knowledge of common cell biology and biochemistry laboratory procedures (e.g. flow cytometry, ELISA, qPCR, IHC etc.) Broad practical experience with or knowledge of common cell biology and biochemistry laboratory procedures (e.g. flow cytometry, ELISA, qPCR, IHC etc.
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CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates ("ADCs"), T-cell engaging bispecific antibodies ("TCBs"), and immune modulators such as cytokines and checkpoint inhibitors ("CPIs.
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The Vice Preside of CMC Radiopharmaceutical Process Development will provide oversights to cell line development, antibody process development and scale up, conjugation and radio drug substance and drug product development and GMP manufacturing.
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Vera is also developing MAU868, a monoclonal antibody designed to neutralize infection with BK Virus, a polyomavirus that can have devastating consequences in certain settings such as kidney transplant.
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Familiarity with synthetic biology and sequencing products and processes, drug development landscape, antibody therapies, and personalized medicine,. Familiarity with synthetic biology and sequencing products and processes, drug development landscape, antibody therapies, and personalized medicine.
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Vir Biotechnology (Vir) is seeking a Summer Research Associate reporting to a Scientist II, Analytical Development Bioassays to lead development of bioassays to interrogate the mechanism of action for antibody and other biologic therapeutics.
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Extensive experience with formulation development and tox/clinical in-use evaluation for monoclonal antibodies, bispecifics, antibody-drug conjugates, fusion proteins, and other complex biologics formats, in a wide concentration range from ultra low to high; experience of IND and/or BLA filings.
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Reporting to the Oncology Discovery Therapeutic Area head, you will partner with data science and machine learning (DSML), translational oncology and computational biology colleagues to gain deep insights into the biology and efficacy of antibody drug conjugates (ADCs) with the goal of delivering therapeutics to the right patients.
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Veras lead product candidate is atacicept, a fusion protein self-administered as a subcutaneous injection once weekly that blocks both B lymphocyte stimulator (BLyS) and a proliferation inducing ligand (APRIL), which stimulate B cells and plasma cells to produce autoantibodies contributing to certain autoimmune diseases, including IgA nephropathy (IgAN), also known as Bergers disease and lupus nephritis.
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Resolve cGMP deviations and investigations and assure appropriate corrective and preventive actions (CAPAs) are implemented at CMO and internally. Contribute in the design, development, implementation, maintenance and improvement of Quality Assurance systems and programs to support and manage quality activities at CMO and in the company.
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In this vital role you will be responsible for the development and implementation of the Quantitative Clinical Pharmacology, Modeling and Simulation strategies for cutting-edge novel modalities including Bi-specific T-cell engagers, Bi-specific antibodies, oncolytic viruses, antibody-drug-conjugates, CAR-T cells-based therapies in addition to small molecule & mono-clonal antibodies.
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antibody elisa jobs in South San Francisco, CA
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