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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.
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Current working knowledge of cellular and molecular immunology, cell biology, or related discipline, with an applied understanding of antibodies and antibody generation, biologics drug discovery research and disease target evaluation.
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In this role, the successful candidate will design and apply computational methods to prioritize novel drug targets, enable patient enrichment strategies, and guide pre-clinical drug development decisions.
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Basic molecular biology skills (PCR especially; familiarity with library prep preferred) - Proficient in laboratory math (dilutions, cell count-based plating) The Oncology Discovery team at the Oncogenesis Thematic Research Center is seeking a Research Associate to support our drug discovery and characterization efforts.
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Contribute to the development of NGS assays to benefit drug discovery and translational research. Demonstrated expertise in molecular biology techniques, including DNA/RNA extraction & purification, NGS library preparation & QC, PCR, qPCR, etc.
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The Director of Drug Metabolism and Pharmacokinetics (DMPK) and Bioanalysis will oversee the scientific processes involved in conducting and executing in vivo pharmacokinetic (PK) studies, including associated bioanalysis and reporting/interpretation of PK parameters.
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Targeting 10 years of experience as lead statistician on clinical trials in the pharmaceutical industry with significant experience in rare disease drug development. Maintain thorough understanding of current regulatory guidelines and requirements relevant to rare disease drug development.
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Ensures compliance with all federal and local agencies including the Food and Drug Administration (FDA) and local Institutional Review Board (IRB). Ensures compliance with all federal and local agencies including the Food and Drug Administration (FDA and local Institutional Review Board.
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You will work with experienced pharmacometricians, Preclinical Pharmacokinetics, Drug Metabolism, Toxicology, and Clinical Pharmacology colleagues to provide inputs to overall product development plans and to address research and development objectives and issues.
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Demonstrated experience and track record in clinical-stage drug development is a plus. The Pharmacometrics Group applies a range of model informed drug development (MIDD) approaches to support early and late-stage development of small and large molecules.
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MS in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a specific focus on PK and PK/PD modeling and simulation and 10+ years of Pharmaceutical/Biotech industry experience in conduct and/or oversight of late-stage Modeling and Simulation activities, including conduct or oversight of small molecule population pharmacokinetic analyses.
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Penske Automotive Group is an equal opportunity employer and maintains a drug- and alcohol-free workplace. Our interview process typically includes a phone interview, several in-person interviews, background check, reference check, driving record review and a drug screen.
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In Chemistry, Biochemistry, Bioengineering, or Pharmaceutical Sciences with a minimum of 5-8+ years in design and development of nanoparticle-based drug delivery systems or complex biologics. Good track record of scientific publications and patents in the field of lipid nanoparticle-based drug delivery systems is desired.
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The ASR includes crime statistics and institutional policies concerning campus security, such as those concerning alcohol and drug use, crime prevention, the reporting of crimes, sexual assault, and other matters.
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Responsible for coordinating and managing clinical trials including providing all aspects of protocol implementation, including screening for patient eligibility, data collection and analysis, ensuring protocol compliance, adverse drug reaction reports, monitoring patient treatment and toxicities, laboratory and specimen collection and submission, and maintenance of accurate and complete clinical research files.
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drug job in San Diego, CA
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